catalog number :
MBS9416094
products full name :
TFDP2 Antibody
products short name :
[TFDP2]
products name syn :
[DP2]
other names :
[transcription factor Dp-2 isoform 1; Transcription factor Dp-2; transcription factor Dp-2; transcription factor Dp-2; E2F dimerization partner 2]
products gene name :
[TFDP2]
other gene names :
[TFDP2; TFDP2; DP2; DP2]
uniprot entry name :
TFDP2_HUMAN
specificity :
The antibody detects endogenous levels of total TFDP2 protein.
purity :
Antigen Affinity Purification
form :
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
concentration :
1.8 mg/ml
storage stability :
Store at -20°C.
tested application :
Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: 1:30-1:150
image1 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen Type: Protein. Immunogen: Full length fusion protein of human TFDP2
products categories :
Total protein Ab
products description :
The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants.
ncbi acc num :
NP_001171609.1
ncbi gb acc num :
NM_001178138.1
ncbi pathways :
Cell Cycle Pathway (1269741); Cell Cycle, Mitotic Pathway (1269763); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Cyclin D Associated Events In G1 Pathway (1269767); E2F Transcription Factor Network Pathway (137934); G0 And Early G1 Pathway (1269765); G1 Phase Pathway (1269766); G1 To S Cell Cycle Control Pathway (198805); Gene Expression Pathway (1269649)
uniprot summary :
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812).