catalog number :
MBS9415870
products full name :
TREM1 Antibody
products short name :
[TREM1]
products name syn :
[CD354; TREM-1]
other names :
[triggering receptor expressed on myeloid cells 1 isoform 2; Triggering receptor expressed on myeloid cells 1; triggering receptor expressed on myeloid cells 1; triggering receptor expressed on myeloid cells 1; Triggering receptor expressed on monocytes 1; CD_antigen: CD354]
products gene name :
[TREM1]
other gene names :
[TREM1; TREM1; CD354; TREM-1; TREM-1]
uniprot entry name :
TREM1_HUMAN
specificity :
The antibody detects endogenous levels of total TREM1 protein.
purity :
Antigen Affinity Purification
form :
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
concentration :
1.0 mg/ml
storage stability :
Store at -20 degree C
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Western Blot: 1:200-1:1000. Immunohistochemistry: 1:100-1:200
image1 heading :
Immunohistochemical
image2 heading :
Immunohistochemical
image3 heading :
Western Blot (WB)
other info1 :
Immunogen: Full length fusion protein of human TREM1
other info2 :
Immunogen Type: Protein
products categories :
Total protein Ab
products description :
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells.This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoformshave been noted for this gene.
ncbi acc num :
NP_001229518.1
ncbi gb acc num :
NM_001242589.2
ncbi pathways :
Adaptive Immune System Pathway (1269171); Cell Surface Interactions At The Vascular Wall Pathway (1269373); DAP12 Interactions Pathway (1269283); Hemostasis Pathway (1269340); Immune System Pathway (1269170); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1269201); Innate Immune System Pathway (1269203)
uniprot summary :
TREM1: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: plasma membrane. Molecular Function: receptor activity. Biological Process: humoral immune response; innate immune response; leukocyte migration; regulation of immune response