catalog number :
MBS9415370
products full name :
Metalloproteinase inhibitor 3 Polyclonal Antibody
products short name :
[Metalloproteinase inhibitor 3]
products name syn :
[Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP3]
other names :
[metalloproteinase inhibitor 3; Metalloproteinase inhibitor 3; metalloproteinase inhibitor 3; TIMP metallopeptidase inhibitor 3; Protein MIG-5; Tissue inhibitor of metalloproteinases 3; TIMP-3]
other gene names :
[TIMP3; TIMP3; SFD; K222; K222TA2; HSMRK222; TIMP-3]
uniprot entry name :
TIMP3_HUMAN
specificity :
The antibody detects endogenous level of total Metalloproteinase inhibitor 3 polyclonal antibody.
purity :
Caprylic Acid Ammonium Sulfate Precipitation purified
form :
Preservative: 0.03% Proclin 300 . Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
concentration :
1.0 mg/ml
storage stability :
Store at -20°C
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Western Blot: 1:500 - 1:1000
image1 heading :
Western Blot (WB)
other info1 :
Immunogen: Recombinant Human Metalloproteinase inhibitor 3 protein. Calculated MW: 24 kD
other info2 :
Immunogen Type: Protein
products categories :
Total protein Ab
products description :
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
ncbi acc num :
NP_000353.1
ncbi gb acc num :
NM_000362.4
ncbi pathways :
Angiogenesis Pathway (198772); Endochondral Ossification Pathway (198812); Matrix Metalloproteinases Pathway (198900); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928); Oncostatin M Signaling Pathway (711361); Proteoglycans In Cancer Pathway (782000); Proteoglycans In Cancer Pathway (782054)
uniprot summary :
TIMP3: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family. Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 22q12.3. Cellular Component: extracellular matrix; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrix. Molecular Function: metalloendopeptidase inhibitor activity; protease binding; protein binding. Biological Process: negative regulation of membrane protein ectodomain proteolysis; platelet degranulation; response to organic substance. Disease: Fundus Dystrophy, Pseudoinflammatory, Of Sorsby