MASP1 Antibody | MyBioSource MBS9415300 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MASP1 Antibody

catalog :

MBS9415300

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Gel: 8%SDS-PAGE Lysate: 40 g Lane 1-2: Hela cell and mouse liver tissue Primary antibody: 1/400 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 3 minutes

image 2 :

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/20. (Original magnification: ¡200)

product information

catalog number :

MBS9415300

products type :

Antibody

products full name :

MASP1 Antibody

products short name :

[MASP1]

products name syn :

[3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1]

other names :

[mannan-binding lectin serine protease 1 isoform 3; Mannan-binding lectin serine protease 1; mannan-binding lectin serine protease 1; mannan binding lectin serine peptidase 1; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; Mannose-binding lectin-associated serine protease 1; MASP-1]

products gene name :

[MASP1]

other gene names :

[MASP1; MASP1; 3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1; CRARF; CRARF1; PRSS5; MASP-1; RaRF]

uniprot entry name :

MASP1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

380

specificity :

The antibody detects endogenous levels of total MASP1 protein.

purity :

Antigen Affinity Purification

form :

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

concentration :

1 mg/ml

storage stability :

Store at -20°C

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Western Blot: 1:200-1:1000. Immunohistochemistry: 1:25-1:100

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Fusion protein of human MASP1. Calculated MW: 79kD

other info2 :

Immunogen Type: Protein

products categories :

Total protein Ab

products description :

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation.

ncbi gi num :

73623026

ncbi acc num :

NP_001027019.1

ncbi gb acc num :

NM_001031849.2

uniprot acc num :

P48740

ncbi pathways :

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (1269241); Creation Of C4 And C2 Activators Pathway (1269243); Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway (1269245); Immune System Pathway (1269170); Initial Triggering Of Complement Pathway (1269242)

uniprot summary :

MASP1: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Defects in MASP1 are the cause of 3MC syndrome type 1 (3MC1). 3MC1 is a disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3q27-q28. Cellular Component: extracellular region; extracellular space. Molecular Function: calcium ion binding; calcium-dependent protein binding; peptidase activity; protein binding; protein homodimerization activity; serine-type endopeptidase activity. Biological Process: complement activation; complement activation, lectin pathway; receptor-mediated endocytosis. Disease: 3mc Syndrome 1

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage