ADRB2 Antibody | MyBioSource MBS9414764 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ADRB2 Antibody

catalog :

MBS9414764

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Gel: 10%SDS-PAGELane1: Hela cell lysateLane2: A549 cell lysateLysates: 30ug per lanePrimary antibody: 1/600 dilutionSecondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute

image 2 :

The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using MBS9414764 (ADRB2 Antibody) at dilution 1/20, on the right is treated with the synthetic peptide.

product information

catalog number :

MBS9414764

products type :

Antibody

products full name :

ADRB2 Antibody

products short name :

[ADRB2]

products name syn :

[Adrenoceptor beta 2, surface, BAR, B2AR, ADRBR, ADRB2R, BETA2AR]

other names :

[beta-2 adrenergic receptor; Beta-2 adrenergic receptor; beta-2 adrenergic receptor; adrenoceptor beta 2, surface; Beta-2 adrenoreceptor; Beta-2 adrenoceptor]

products gene name :

[ADRB2]

other gene names :

[ADRB2; ADRB2; BAR; B2AR; ADRBR; ADRB2R; BETA2AR; ADRB2R; B2AR; Beta-2 adrenoceptor]

uniprot entry name :

ADRB2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

413

specificity :

The antibody detects endogenous level of total ADRB2 protein.

form :

Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.

storage stability :

Store at -20°C/1 year

tested application :

ELISA (EIA, Western Blot (WB), Immunohistochemistry (IHC)

app notes :

ELISA: 1:1000-1:2000. Western blotting: 1:1000-1:2000. Immunohistochemistry: 1:15-1:50

image1 heading :

Testing Data

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to a region derived from 21-33 amino acids of Human adrenoceptor beta 2, surface. Predicted MW: 46kd

other info2 :

Target Name: ADRB2

products categories :

Total protein Ab

products description :

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.

ncbi gi num :

4501969

ncbi acc num :

NP_000015

ncbi gb acc num :

NM_000024.5

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Adrenoceptors Pathway (1269555); Amine Ligand-binding Receptors Pathway (1269553); Arf6 Signaling Events Pathway (138034); Arf6 Trafficking Events Pathway (137954); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545)

ncbi summary :

uniprot summary :

ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 5q31-q32. Cellular Component: lysosome; integral to plasma membrane; apical plasma membrane; plasma membrane; nucleus; receptor complex; endosome. Molecular Function: protein binding; potassium channel regulator activity; protein homodimerization activity; beta2-adrenergic receptor activity; norepinephrine binding; adenylate cyclase binding. Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; diet induced thermogenesis; transmembrane receptor protein tyrosine kinase activation (dimerization); negative regulation of multicellular organism growth; regulation of vasodilation; adenylate cyclase activation; regulation of sodium ion transport; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; positive regulation of protein ubiquitination; heat generation; negative regulation of smooth muscle contraction; brown fat cell differentiation; endosome to lysosome transport; positive regulation of transcription from RNA polymerase II promoter; response to cold; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; bone resorption. Disease: Obesity; Asthma, Susceptibility To

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

255

more info or order :

MyBioSource product webpage