TLR8 Antibody | MyBioSource MBS9414718 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TLR8 Antibody

catalog :

MBS9414718

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various cell lines,using TLR8 antibody.

image 2 :

Immunofluorescence analysis of MCF7 cell using TLR8 antibody. Blue: DAPI for nuclear staining.

product information

catalog number :

MBS9414718

products type :

Antibody

products full name :

TLR8 Antibody

products short name :

[TLR8]

products name syn :

[CD288; TLR8]

other names :

[toll-like receptor 8 isoform 1; Toll-like receptor 8; toll-like receptor 8; toll-like receptor 8; CD_antigen: CD288]

products gene name :

[TLR8]

other gene names :

[TLR8; TLR8; CD288]

uniprot entry name :

TLR8_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1059

specificity :

The antibody detects endogenous level of total TLR8 protein.

purity :

Antibodies were purified by affinity purification using immunogen.

form :

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1.0 mg/ml

storage stability :

Store at -20°C.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

Western blotting: 1:500 - 1:2000. Immunohistochemistry: 1:50 - 1:100. Immunofluorescence: 1:50 - 1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunofluorescence (IF)

other info1 :

Immunogen Type: Recombinant Protein. Immunogen Description: Recombinant protein of human TLR8.

other info2 :

Target Name: TLR8. SDS-PAGE MW: 120 KD

products categories :

Total protein Ab

products description :

The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunity. The TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductions. TLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domain. Three TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressed. TLR7 is expressed in lung, placenta and spleen. TLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytes. TLR7, TLR8 and TLR9 stimulate the NF B signaling pathway, suggesting that they play a role in the immune response.

ncbi gi num :

20302166

ncbi acc num :

NP_057694.2

ncbi gb acc num :

NM_016610.3

uniprot acc num :

Q9NR97

ncbi pathways :

Immune System Pathway (1269170); Innate Immune System Pathway (1269203); MyD88 Dependent Cascade Initiated On Endosome Pathway (1269228); Regulation Of Toll-like Receptor Signaling Pathway (920955); TRAF6 Mediated IRF7 Activation In TLR7/8 Or 9 Signaling Pathway (1269232); TRAF6 Mediated Induction Of NFkB And MAP Kinases Upon TLR7/8 Or 9 Activation Pathway (1269229); Toll Like Receptor 7/8 (TLR7/8) Cascade Pathway (1269227); Toll Like Receptor 9 (TLR9) Cascade Pathway (1269233); Toll-Like Receptors Cascades Pathway (1269204); Toll-like Receptor Signaling Pathway (83076)

ncbi summary :

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

uniprot summary :

TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: Xp22. Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane. Molecular Function: single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; receptor activity; drug binding. Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; response to virus; positive regulation of interleukin-8 biosynthetic process; microglial cell activation; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of innate immune response; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; immunoglobulin mediated immune response; toll-like receptor 9 signaling pathway; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage