catalog number :
MBS9414381
products full name :
PJA2 antibody
products short name :
[PJA2]
products name syn :
[RNF131; Neurodap1]
other names :
[E3 ubiquitin-protein ligase Praja-2; E3 ubiquitin-protein ligase Praja-2; E3 ubiquitin-protein ligase Praja-2; praja ring finger 2, E3 ubiquitin protein ligase; RING finger protein 131]
products gene name :
[PJA2]
other gene names :
[PJA2; PJA2; RNF131; Neurodap1; KIAA0438; RNF131; Praja2]
uniprot entry name :
PJA2_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
The antibody detects endogenous level of total PJA2 antibody.
purity :
Antibodies were purified by affinity purification using immunogen.
form :
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
1.0 mg/ml
storage stability :
Store at -20 degree C
tested application :
Western Blot (WB), Immunofluorescence (IF)
app notes :
Western blotting: 1:500 - 1:2000. Immunofluorescence: 1:50 - 1:100
image1 heading :
Immunofluorescence (IF)
other info1 :
Immunogen Type: Recombinant Protein. Immunogen Description: Recombinant protein of human PJA2.
other info2 :
Target Name: PJA2
products categories :
Total protein Ab
products description :
Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes.
ncbi acc num :
NP_055634.3
ncbi gb acc num :
NM_014819.4
ncbi pathways :
Adaptive Immune System Pathway (1269171); Antigen Processing: Ubiquitination Proteasome Degradation Pathway (1269193); Class I MHC Mediated Antigen Processing Presentation Pathway (1269192); Immune System Pathway (1269170)
uniprot summary :
PJA2: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA- mediated long-term memory processes. Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2. The phosphorylated form interacts with PRKAR1A, PRKAR2A and PRKAR2B. Binds the catalytic subunits of cAMP-dependent protein kinase. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase. Chromosomal Location of Human Ortholog: 5q21.3. Cellular Component: Golgi membrane; postsynaptic membrane; endoplasmic reticulum membrane; cytoplasm; postsynaptic density; plasma membrane; cell junction. Molecular Function: zinc ion binding; ubiquitin-protein ligase activity; ligase activity. Biological Process: long-term memory; protein ubiquitination