CLEC7A Antibody | MyBioSource MBS9414183 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CLEC7A Antibody

catalog :

MBS9414183

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Gel: 12%SDS-PAGE Lysates (from left to right): SP20 and RAW264.7 cell Amount of lysate: 40ug per lane Primary antibody: 1/200 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds

image 2 :

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/5.

product information

catalog number :

MBS9414183

products type :

Antibody

products full name :

CLEC7A Antibody

products short name :

[CLEC7A]

products name syn :

[BGR; CANDF4; DECTIN1; CLECSF12]

other names :

[C-type lectin domain family 7 member A isoform b; C-type lectin domain family 7 member A; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1]

products gene name :

[CLEC7A]

other gene names :

[CLEC7A; CLEC7A; BGR; CD369; CANDF4; DECTIN1; CLECSF12; BGR; CLECSF12; DECTIN1; DC-associated C-type lectin 1; Dectin-1]

uniprot entry name :

CLC7A_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

201

specificity :

The antibody detects endogenous levels of total CLEC7A protein.

purity :

Antigen affinity purification.

form :

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

concentration :

0.2 mg/ml

storage stability :

Store at -20 degree C

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Western blotting: 1:500-1:2000. Immunohistochemistry: 1:10-1:50

image1 heading :

Testing Data

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Recombinant Protein. Immunogen Description: Full length fusion protein

other info2 :

Target Name: CLEC7A

products categories :

Total protein Ab

products description :

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

ncbi gi num :

13384604

ncbi acc num :

NP_072092.2

ncbi gb acc num :

NM_022570.4

uniprot acc num :

Q9BXN2

ncbi mol weight :

28kd

ncbi pathways :

C-type Lectin Receptors (CLRs) Pathway (1269303); CLEC7A (Dectin-1) Signaling Pathway (1269304); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); Phagosome Pathway (153910); Phagosome Pathway (153859); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)

ncbi summary :

uniprot summary :

dectin-1: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 12p13.2. Cellular Component: cytoplasm; plasma membrane; integral to membrane. Molecular Function: metal ion binding; MHC protein binding; carbohydrate binding; pattern recognition receptor activity. Biological Process: T cell activation; innate immune response; carbohydrate mediated signaling; cell recognition; phagocytosis, recognition; pattern recognition receptor signaling pathway; inflammatory response; defense response to protozoan. Disease: Aspergillosis, Susceptibility To; Candidiasis, Familial, 4

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage