antibody

Histamine H2 Receptor antibody

MBS9414140

0.1 mL

320 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry, immunocytochemistry

Antibody

Histamine H2 Receptor antibody

[Histamine H2 Receptor]

[H2R]

[histamine H2 receptor isoform 2; Histamine H2 receptor; histamine H2 receptor; histamine receptor H2; Gastric receptor I]

[HRH2; HRH2; H2R; H2R; HH2R]

HRH2_HUMAN

Polyclonal

Rabbit

Human

359

Purified by antigen-affinity chromatography.

Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.

0.8 mg/ml

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Western blotting: 1:500-1:3000. Immunohistochemistry: 1:50-1:500. Immunofluorescence: 1:100-1:200

Western Blot (WB)

Immunohistochemistry (IHC)

Immunofluorescence (IF)

Immunogen Type: Peptide. Immunogen Description: Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 11 (P25021) of Histamine H2 Receptor

Target Name: Histamine H2 Receptor

Total protein Ab

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

13435405

NP_071640

NM_022304.2

Predicted: 40kd

Amine Ligand-binding Receptors Pathway (1269553); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (s) Signalling Events Pathway (1269575); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886); Gastric Acid Secretion Pathway (154409); Gastric Acid Secretion Pathway (154383)

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

H2R: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 5q35.2. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: histamine receptor activity. Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; gland development; gastrin-induced gastric acid secretion; gut development; histamine-induced gastric acid secretion; positive regulation of vasoconstriction; regulation of synaptic plasticity; visual learning; immune response; memory

0.1 mL

320 USD