catalog number :
MBS9413679
products full name :
PPP1R3C Antibody
products short name :
[PPP1R3C]
other names :
[protein phosphatase 1 regulatory subunit 3C; Protein phosphatase 1 regulatory subunit 3C; protein phosphatase 1 regulatory subunit 3C; protein phosphatase 1, regulatory subunit 3C; Protein phosphatase 1 regulatory subunit 5; PP1 subunit R5; Protein targeting to glycogen; PTG]
products gene name :
[PPP1R3C]
other gene names :
[PPP1R3C; PPP1R3C; PPP1R5; PP1 subunit R5; PTG]
uniprot entry name :
PPR3C_HUMAN
reactivity :
Human, Rat, Mouse
purity :
Affinity purified
form :
PBS, pH 7.4 with 0.02% sodium azide.
concentration :
1.0 mg/ml
storage stability :
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ELISA: 1:20000-1:80000. WB: 1:200-1:1000. IHC: 1:100-1:500
image1 heading :
Western Blot (WB)
other info1 :
Immunogen Type: Recombinant Protein. Immunogen Description: Rabbit polyclonal PPP1R3C antibody was raised against a recombinant human PPP1R3C protein 79- 295aa (BC012625).
other info2 :
Target Name: PPP1R3C
products categories :
Total protein Ab
ncbi acc num :
NP_005389.1
ncbi gb acc num :
NM_005398.5
ncbi pathways :
Disease Pathway (1268854); Diseases Of Carbohydrate Metabolism Pathway (1268940); Diseases Of Metabolism Pathway (1268939); Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); Glucose Metabolism Pathway (1269959); Glycogen Storage Diseases Pathway (1268953); Glycogen Synthesis Pathway (1269962); Insulin Signaling Pathway (83090); Insulin Signaling Pathway (501); Metabolism Pathway (1269956)
ncbi summary :
This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals. [provided by RefSeq, Oct 2011]
uniprot summary :
PPP1R3C: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit. Chromosomal Location of Human Ortholog: 10q23-q24. Cellular Component: cytosol. Molecular Function: protein binding; protein serine/threonine phosphatase activity; protein phosphatase binding. Biological Process: glycogen biosynthetic process; dephosphorylation; carbohydrate metabolic process; glucose metabolic process; pathogenesis