antibody

TBX5 Antibody

MBS9412700

0.1 mL

255 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, immunohistochemistry

Antibody

TBX5 Antibody

[TBX5]

[HOS]

[T-box transcription factor TBX5 isoform 1; T-box transcription factor TBX5; T-box transcription factor TBX5; T-box 5]

[TBX5]

[TBX5; TBX5; HOS; T-box protein 5]

TBX5_HUMAN

Polyclonal

Rabbit

Human, Mouse

The antibody detects endogenous levels of total TBX5 protein.

Antigen affinity purification.

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

2.3 mg/ml

Store at -20 degree C

Western Blot (WB), Immunohistochemistry (IHC)

Western blotting: 1:200-1:1000. Immunohistochemistry: 1:50-1:200

Testing Data

Immunohistochemistry (IHC)

Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human T-box 5

Target Name: TBX5

Total protein Ab

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.

18201892

NP_000183

NM_000192.3

Q99593

SDS-PAGE: 58kd

Cardiac Progenitor Differentiation Pathway (712094); Gene Expression Pathway (1269649); Generic Transcription Pathway (1269650); Heart Development Pathway (198802); YAP1- And WWTR1 (TAZ)-stimulated Gene Expression Pathway (1269653)

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

TBX5: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Defects in TBX5 are the cause of Holt-Oram syndrome (HOS). HOS is a developmental disorder affecting the heart and upper limbs. It is characterized by thumb anomaly and atrial septal defects. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 12q24.1. Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus. Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor binding; transcription factor activity. Biological Process: embryonic forelimb morphogenesis; pericardium development; transcription initiation from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; heart development; pattern specification process; cardiac muscle cell differentiation; forelimb morphogenesis; negative regulation of cell proliferation; apoptotic nuclear changes; cell-cell signaling; negative regulation of cardiac muscle cell proliferation; positive regulation of cardioblast differentiation; morphogenesis of an epithelium; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell migration; positive regulation of cardiac muscle cell proliferation; lung development; embryonic limb morphogenesis. Disease: Holt-oram Syndrome

0.1 mL

255 USD