MKP-2 Polyclonal Antibody | MyBioSource MBS9412670 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MKP-2 Polyclonal Antibody

catalog :

MBS9412670

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of HEPG2-UV cells using MKP-2 Polyclonal Antibody

product information

catalog number :

MBS9412670

products type :

Antibody

products full name :

MKP-2 Polyclonal Antibody

products short name :

[MKP-2]

products name syn :

[DUSP4; MKP2; VH2; Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; Mitogen-activated protein kinase phosphatase 2; MAP kinase phosphatase 2; MKP-2]

other names :

[dual specificity protein phosphatase 4 isoform 1; Dual specificity protein phosphatase 4; dual specificity protein phosphatase 4; dual specificity phosphatase 4; Dual specificity protein phosphatase hVH2; Mitogen-activated protein kinase phosphatase 2; MAP kinase phosphatase 2; MKP-2]

products gene name :

[MKP-2]

other gene names :

[DUSP4; DUSP4; TYP; HVH2; MKP2; MKP-2; MKP2; VH2; MAP kinase phosphatase 2; MKP-2]

uniprot entry name :

DUS4_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat, Monkey

sequence length :

394

specificity :

MKP-2 Polyclonal Antibody detects endogenous levels of MKP-2 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Store at -20 degree C/1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

app notes :

Western Blot: 1:500 - 1:2000. Immunohistochemistry: 1:100 - 1:300. ELISA: 1:20000. Not yet tested in other applications.

image1 heading :

Western Blot (WB)

other info1 :

Immunogen Type: peptide. Immunogen Description: Synthesized peptide derived from the Internal region of human MKP-2.

other info2 :

Target Name: MKP-2

products categories :

Total protein Ab

ncbi gi num :

4503417

ncbi acc num :

NP_001385.1

ncbi gb acc num :

NM_001394.6

uniprot acc num :

Q13115

ncbi mol weight :

44kD

ncbi pathways :

ARMS-mediated Activation Pathway (1269471); Activated TLR4 Signalling Pathway (1269236); Axon Guidance Pathway (1270303); B Cell Receptor Signaling Pathway (198909); Cytokine Signaling In Immune System Pathway (1269310); DAP12 Interactions Pathway (1269283); DAP12 Signaling Pathway (1269284); Developmental Biology Pathway (1270302); Downstream Signal Transduction Pathway (1269479); Downstream Signaling Of Activated FGFR1 Pathway (1269392)

ncbi summary :

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

MKP-2: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Induced by hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) in human endothelial cells. Two alternatively spliced isoforms have been described. In addition, multiple polyadenylation sites have been reported. Contains 1 rhodanese domain. Protein type: EC 3.1.3.16; Protein phosphatase, dual-specificity; EC 3.1.3.48. Chromosomal Location of Human Ortholog: 8p12-p11. Cellular Component: nucleoplasm; nucleus. Molecular Function: protein tyrosine/threonine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity. Biological Process: nerve growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid dephosphorylation; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; endoderm formation; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; inactivation of MAPK activity

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

255

more info or order :

MyBioSource product webpage