BAAT Antibody | MyBioSource MBS9411615 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

BAAT Antibody

catalog :

MBS9411615

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Gel: 8%SDS-PAGE Lysates (from left to right): Human normal liver and mouse pancreas tissue Amount of lysate: 40ug per lane Primary antibody: 1/650 dilution Secondary antibody dilution: 1/8000 Exposure time: 10 seconds

image 2 :

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/30.

product information

catalog number :

MBS9411615

products type :

Antibody

products full name :

BAAT Antibody

products short name :

[BAAT]

products name syn :

[BAT; BACAT]

other names :

[bile acid-CoA:amino acid N-acyltransferase; Bile acid-CoA:amino acid N-acyltransferase; bile acid-CoA:amino acid N-acyltransferase; bile acid CoA:amino acid N-acyltransferase; Glycine N-choloyltransferase; Long-chain fatty-acyl-CoA hydrolase (EC:3.1.2.2)]

products gene name :

[BAAT]

other gene names :

[BAAT; BAAT; BAT; BACAT; BACAT; BAT]

uniprot entry name :

BAAT_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

418

specificity :

The antibody detects endogenous levels of total BAAT protein.

purity :

Antigen affinity purification.

form :

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

concentration :

1.3 mg/ml

storage stability :

Store at -20 degree C

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Western blotting: 1:500-1:2000. Immunohistochemistry: 1:25-1:100

image1 heading :

Testing Data

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Recombinant Protein. Immunogen Description: Fusion protein corresponding to residues near the C terminal of human bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)

other info2 :

Target Name: BAAT

products categories :

Total protein Ab

products description :

The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene.

ncbi gi num :

189083866

ncbi acc num :

NP_001121082.1

ncbi gb acc num :

NM_001127610.1

uniprot acc num :

Q14032

ncbi mol weight :

46kd

ncbi pathways :

Bile Acid And Bile Salt Metabolism Pathway (1270040); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Biosynthesis Of Unsaturated Fatty Acids Pathway (83034); Biosynthesis Of Unsaturated Fatty Acids Pathway (429); Conjugated Bile Acid Biosynthesis, Cholate = Taurocholate/glycocholate Pathway (472628); Conjugated Bile Acid Biosynthesis, Cholate = Taurocholate/glycocholate Pathway (468366); Drug Induction Of Bile Acid Pathway (698755); Metabolic Pathways (132956); Metabolism Pathway (1269956)

ncbi summary :

uniprot summary :

BAAT: Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs. Defects in BAAT are involved in familial hypercholanemia (FHCA). FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Belongs to the C/M/P thioester hydrolase family. Protein type: Transferase; Lipid Metabolism - primary bile acid biosynthesis; EC 2.3.1.65; EC 3.1.2.2; Other Amino Acids Metabolism - taurine and hypotaurine; Hydrolase; Lipid Metabolism - unsaturated fatty acid biosynthesis. Chromosomal Location of Human Ortholog: 9q22.3. Cellular Component: peroxisomal matrix; peroxisome; cytosol. Molecular Function: N-acyltransferase activity; palmitoyl-CoA hydrolase activity; glycine N-choloyltransferase activity; receptor binding. Biological Process: bile acid and bile salt transport; glycine metabolic process; bile acid biosynthetic process; organ regeneration; acyl-CoA metabolic process; bile acid metabolic process; liver development; fatty acid metabolic process; taurine metabolic process. Disease: Hypercholanemia, Familial

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage