CHOP Polyclonal Antibody | MyBioSource MBS9410117 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CHOP Polyclonal Antibody

catalog :

MBS9410117

quantity :

0.05 mL

price :

190 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9410117

products type :

Antibody

products full name :

CHOP Polyclonal Antibody

products short name :

CHOP

products name syn :

DDIT3; CHOP; CHOP10; GADD153; DNA damage-inducible transcript 3 protein; DDIT-3; C/EBP-homologous protein; CHOP; C/EBP-homologous protein 10; CHOP-10; Growth arrest and DNA damage-inducible protein GADD153

other names :

DNA damage-inducible transcript 3 protein isoform 1; DNA damage-inducible transcript 3 protein; DNA damage-inducible transcript 3 protein; DNA-damage-inducible transcript 3; C/EBP zeta; C/EBP-homologous protein; CHOP; C/EBP-homologous protein 10; CHOP-10; CCAAT/enhancer-binding protein homologous protein; Growth arrest and DNA damage-inducible protein GADD153

products gene name :

CHOP

other gene names :

DDIT3; DDIT3; CHOP; CEBPZ; CHOP10; CHOP-10; GADD153; CHOP; CHOP10; GADD153; DDIT-3; CHOP; CHOP-10

uniprot entry name :

DDIT3_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

192

specificity :

CHOP Polyclonal Antibody detects endogenous levels of CHOP protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Store at -20 degree C/1 year

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

app notes :

Western Blot: 1:500 - 1:2000. Immunohistochemistry: 1:100 - 1:300. Immunofluorescence: 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

other info1 :

Immunogen Type: peptide. Immunogen Description: Synthesized peptide derived from human CHOP around the non-phosphorylation site of S30. SDS-PAGE MW: 19kd

other info2 :

Target Name: CHOP

products categories :

Total protein Ab

ncbi gi num :

304282225

ncbi acc num :

NP_001181982.1

ncbi gb acc num :

NM_001195053.1

uniprot acc num :

P35638

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); ATF4 Activates Genes Pathway (1268762); ATF6-alpha Activates Chaperone Genes Pathway (1268758); ATF6-alpha Activates Chaperones Pathway (1268757); Adipogenesis Pathway (198832); MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Metabolism Of Proteins Pathway (1268677); Non-alcoholic Fatty Liver Disease (NAFLD) Pathway (862188)

ncbi summary :

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]

uniprot summary :

CHOP: a transcriptional-regulatory protein of the bZIP family. Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA. May play an important role in melanoma progression. CK2-mediated phosphorylation inhibits its transcriptional activity. Up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform. Protein type: Oncoprotein; Transcription factor; Autophagy; DNA-binding. Chromosomal Location of Human Ortholog: 12q13.1-q13.2. Cellular Component: nucleoplasm; late endosome; cytosol; nucleus. Molecular Function: leucine zipper domain binding; protein binding; DNA binding; protein heterodimerization activity; transcription factor binding; transcription corepressor activity; transcription factor activity. Biological Process: proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-8 production; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; cell cycle arrest; ER overload response; regulation of transcription in response to stress; Wnt receptor signaling pathway; negative regulation of protein kinase B signaling cascade; unfolded protein response; negative regulation of transcription factor activity; mRNA transcription from RNA polymerase II promoter; blood vessel maturation; response to unfolded protein; response to starvation; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cell redox homeostasis; release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; inhibition of CREB transcription factor; negative regulation of transcription, DNA-dependent; negative regulation of myoblast differentiation; response to DNA damage stimulus. Disease: Myxoid Liposarcoma

size1 :

0.05 mL

price1 :

190 USD

size2 :

0.1 mL

price2 :

225

more info or order :

MyBioSource product webpage