catalog number :
MBS9409765
products full name :
CD48 Antibody
products short name :
[CD48]
products name syn :
[BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102]
other names :
[CD48 antigen isoform 1; CD48 antigen; CD48 antigen; CD48 molecule; B-lymphocyte activation marker BLAST-1; BCM1 surface antigen; Leukocyte antigen MEM-102; SLAM family member 2; SLAMF2; Signaling lymphocytic activation molecule 2; TCT.1; CD_antigen: CD48]
products gene name :
[CD48]
other gene names :
[CD48; CD48; BCM1; BLAST; hCD48; mCD48; BLAST1; SLAMF2; MEM-102; BCM1; BLAST1; SLAMF2]
uniprot entry name :
CD48_HUMAN
reactivity :
Human, Mouse
specificity :
The antibody detects endogenous levels of total CD48 protein.
purity :
Antigen affinity purification.
form :
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
concentration :
2.2 mg/ml
storage stability :
Store at -20°C
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Western blotting: 1:200-1:1000. Immunohistochemistry: 1:50-1:200
image1 heading :
Testing Data
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human CD48 molecule. SDS-PAGE MW: 28 kD
other info2 :
Target Name: CD48
products categories :
Total protein Ab
products description :
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
ncbi gb acc num :
NM_001778.3
ncbi pathways :
Cell Surface Interactions At The Vascular Wall Pathway (1269373); Gastric Cancer Network 2 Pathway (760637); Hemostasis Pathway (1269340); Natural Killer Cell Mediated Cytotoxicity Pathway (83079); Natural Killer Cell Mediated Cytotoxicity Pathway (490)
ncbi summary :
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
uniprot summary :
CD48: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. Protein type: Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 1q21.3-q22. Cellular Component: membrane; integral to plasma membrane; plasma membrane; lipid raft. Molecular Function: protein binding; receptor activity. Biological Process: defense response; blood coagulation; leukocyte migration