product summary
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company name :
MyBioSource
product type :
antibody
product name :
CD163 Antibody
catalog :
MBS9409179
quantity :
0.1 mL
price :
255 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
immunohistochemistry
more info or order :
image
image 1 :
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/30.
image 2 :
Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/30.
product information
catalog number :
MBS9409179
products type :
Antibody
products full name :
CD163 Antibody
products short name :
[CD163]
products name syn :
[M130; MM130]
other names :
[scavenger receptor cysteine-rich type 1 protein M130 isoform a; Scavenger receptor cysteine-rich type 1 protein M130; scavenger receptor cysteine-rich type 1 protein M130; CD163 molecule; Hemoglobin scavenger receptor; CD_antigen: CD163]
products gene name :
[CD163]
other gene names :
[CD163; CD163; M130; MM130; M130; sCD163]
uniprot entry name :
C163A_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
1156
specificity :
The antibody detects endogenous levels of total CD163 protein.
purity :
Antigen affinity purification.
form :
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol
concentration :
0.9 mg/ml
storage stability :
Store at -20°C.
tested application :
Immunohistochemistry (IHC)
app notes :
Immunohistochemistry: 1:25-1:100
image1 heading :
Immunohistochemistry (IHC)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human CD163 molecule
products categories :
Total protein Ab
products description :
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
ncbi gi num :
344179110
ncbi acc num :
NP_004235
ncbi gb acc num :
NM_004244.5
uniprot acc num :
Q86VB7
ncbi pathways :
Binding And Uptake Of Ligands By Scavenger Receptors Pathway (1269897); Scavenging Of Heme From Plasma Pathway (1269898); Vesicle-mediated Transport Pathway (1269876)
ncbi summary :
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
uniprot summary :
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
size1 :
0.1 mL
price1 :
255 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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