Lipe Antibody | MyBioSource MBS9408847 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Lipe Antibody

catalog :

MBS9408847

quantity :

0.1 mL

price :

320 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of lipe in human lymph node tissue lysate with lipe antibody at (A) 0.5 and (B) 1 ug/mL.

image 2 :

Immunohistochemistry of lipe in human lymph node tissue with lipe antibody at 2.5 ug/mL.

product information

catalog number :

MBS9408847

products type :

Antibody

products full name :

Lipe Antibody

products short name :

[Lipe]

products name syn :

[hormone-sensitive lipase, HSL]

other names :

[lipase, hormone-sensitive; Hormone-sensitive lipase; hormone-sensitive lipase; lipase, hormone-sensitive]

products gene name :

[Lipe]

other gene names :

[LIPE; LIPE; HSL; LHS; AOMS4; FPLD6; HSL]

uniprot entry name :

LIPS_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1076

purity :

Affinity chromatography purified via peptide column

form :

Supplied in PBS containing 0.02% sodium azide.

concentration :

1 mg/mL

storage stability :

Can be stored at -20°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Peptide. Immunogen Description: Raised against a 14 amino acid peptide from near the carboxy terminus of human lipe.

other info2 :

Target Name: Lipe

products categories :

Total protein Ab

products description :

Although initially described as an adipocyte-specific triacylglycerol lipase, lipe (also known as hormone-specific lipase or HSL) is expressed in multiple tissues and cell lines. It plays multiple roles in lipid metabolism, including hormone-stimulated lipolysis in adipose tissue and the hydrolysis of cholesterol esters. Lipe is expressed as a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesterol esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. Recently, it was observed that the lack of lipe in genetically obese leptin-null mice inhibited obesity and adipogenesis, suggesting that lipe plays a major role in adipocyte proliferation.

ncbi gi num :

74418834

ncbi acc num :

ABA03168

ncbi pathways :

AMPK Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adipogenesis Pathway (198832); Fatty Acid Beta Oxidation Pathway (198865); Hormone-sensitive Lipase (HSL)-mediated Triacylglycerol Hydrolysis Pathway (1270009); Insulin Signaling Pathway (198845); Insulin Signaling Pathway (83090); Insulin Signaling Pathway (501); Lipid Digestion, Mobilization, And Transport Pathway (1270002)

ncbi summary :

The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

uniprot summary :

HSL: hormone sensitive lipase is a lipolytic enzyme of the GDXG family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin. Protein type: EC 3.1.1.79; Lipase. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: lipid particle; caveola; cytosol. Molecular Function: triacylglycerol lipase activity; hormone-sensitive lipase activity; protein binding; protein kinase binding. Biological Process: cholesterol metabolic process; triacylglycerol catabolic process; diacylglycerol catabolic process; protein amino acid phosphorylation; lipid catabolic process; long-chain fatty acid catabolic process. Disease: Abdominal Obesity-metabolic Syndrome 4

size1 :

0.1 mL

price1 :

320 USD

more info or order :

MyBioSource product webpage