GRM1 Antibody | MyBioSource MBS9408789 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GRM1 Antibody

catalog :

MBS9408789

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Gel: 8%SDS-PAGE. Lysate: 60ug Hela cell. Primary antibody: 1/125 . Secondary antibody dilution: 1/8000. Exposure time: 1 minute

image 2 :

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue at dilution 1/15.

product information

catalog number :

MBS9408789

products type :

Antibody

products full name :

GRM1 Antibody

products short name :

[GRM1]

products name syn :

[GRM1A; mGlu1; GPRC1A; MGLUR1; SCAR13; MGLUR1A]

other names :

[metabotropic glutamate receptor 1 isoform alpha; Metabotropic glutamate receptor 1; metabotropic glutamate receptor 1; glutamate receptor, metabotropic 1]

products gene name :

[GRM1]

other gene names :

[GRM1; GRM1; MGLU1; GPRC1A; MGLUR1; SCAR13; PPP1R85; GPRC1A; MGLUR1; mGluR1]

uniprot entry name :

GRM1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1194

specificity :

The antibody detects endogenous levels of total GRM1 protein.

purity :

Antigen affinity purification.

form :

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

storage stability :

Store at -20 degree C

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Western blotting: 1:500-1:2000. Immunohistochemistry: 1:15-1:50

image1 heading :

Testing Data

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human glutamate receptor, metabotropic 1

other info2 :

Target Name: GRM1

products categories :

Total protein Ab

products description :

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions.

ncbi gi num :

493798972

ncbi acc num :

NP_000829

ncbi gb acc num :

NM_001278064.1

uniprot acc num :

Q13255

ncbi mol weight :

132kd

ncbi pathways :

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway (1269573); Estrogen Signaling Pathway (799177); Estrogen Signaling Pathway (799197); FoxO Signaling Pathway (921162); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway (198839)

ncbi summary :

This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

uniprot summary :

mGluR1: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 3. Chromosomal Location of Human Ortholog: 6q24. Cellular Component: integral to plasma membrane; dendrite; postsynaptic density; plasma membrane; nucleus. Molecular Function: G-protein coupled receptor activity; protein binding; glutamate receptor activity. Biological Process: synaptic transmission; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of synaptic transmission, glutamatergic; activation of MAPKK activity; activation of MAPK activity; metabotropic glutamate receptor signaling pathway; protein kinase C activation; locomotory behavior; regulation of sensory perception of pain; sensory perception of pain. Disease: Spinocerebellar Ataxia, Autosomal Recessive 13

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage