catalog number :
MBS9408781
products full name :
ECRG4 Antibody
products short name :
[ECRG4]
products name syn :
[Esophageal cancer-related gene 4 protein, Augurin, C2orf40]
other names :
[Esophagus cancer-related gene-2; Serine protease inhibitor Kazal-type 7; serine protease inhibitor Kazal-type 7; serine peptidase inhibitor, Kazal type 7 (putative); Esophagus cancer-related gene 2 protein; ECRG-2]
products gene name :
[ECRG4]
other gene names :
[SPINK7; SPINK7; ECG2; ECRG2; ECG2; ECRG-2]
uniprot entry name :
ISK7_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
ECRG4 antibody is predicted to not cross-react with other ECRG family members.
purity :
Affinity chromatography purified via peptide column
form :
Supplied in PBS containing 0.02% sodium azide.
storage stability :
Can be stored at -20°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB)
image1 heading :
Western Blot (WB)
other info1 :
Immunogen Type: Peptide. Immunogen Description: Raised against a 20 amino acid peptide near the carboxy terminus of human ECRG4.
other info2 :
Target Name: ECRG4
products categories :
Total protein Ab
products description :
The esophageal cancer-related gene 4 (ECRG4), also known as Augurin, was identified through differential display screening between esophageal cancer and normal tissue. Hypermethylation of CpG sites in the ECRG4 promoter correlate with ECRG4 downregulation in numerous esophageal squamous cell carcinoma tissues. In transfected cells, overexpression of ECRG4 induced G1 arrest, dephosphorylation of Rb and decreased expression of cyclins D1 and D3. Increased expression of ECRG4 in aged mouse brain is observed compared with young mouse brain. The increased ECRG4 level was accompanied by elevated senescence-associated acidic beta-galactosidase activity, suggesting that ECRG4 is involved in cellular differentiation and senescence.
uniprot summary :
SPINK7: Probable serine protease inhibitor. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 5q32. Cellular Component: extracellular region. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding