antibody

PEPD Antibody

MBS9408303

0.1 mL

255 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

PEPD Antibody

[PEPD]

[PROLIDASE]

[xaa-Pro dipeptidase isoform 1; Xaa-Pro dipeptidase; xaa-Pro dipeptidase; peptidase D; Imidodipeptidase; Peptidase D; Proline dipeptidase; Prolidase]

[PEPD]

[PEPD; PEPD; PROLIDASE; PRD; X-Pro dipeptidase; Prolidase]

PEPD_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

493

The antibody detects endogenous level of total PEPD protein.

Antibodies were purified by affinity purification using immunogen.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0 mg/ml

Store at -20 degree C

Western Blot (WB), Immunohistochemistry (IHC)

Western blotting: 1:500 - 1:2000. Immunohistochemistry: 1:50 - 1:200

Western Blot (WB)

Immunogen Type: Recombinant Protein. Immunogen Description: Recombinant protein of human PEPD.

Target Name: PEPD

Total protein Ab

This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.

149589008

NP_000276.2

NM_000285.3

P12955

54kD

This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

peptidase D: Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen. Defects in PEPD are a cause of prolidase deficiency (PD). Prolidase deficiency is an autosomal recessive disorder associated with iminodipeptiduria. The clinical phenotype includes skin ulcers, mental retardation, recurrent infections, and a characteristic facies. These features, however are incompletely penetrant and highly variable in both age of onset and severity. There is a tight linkage between the polymorphisms of prolidase and the myotonic dystrophy trait. Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; EC 3.4.13.9. Chromosomal Location of Human Ortholog: 19q13.11. Molecular Function: dipeptidase activity; manganese ion binding; aminopeptidase activity; metallocarboxypeptidase activity. Biological Process: amino acid metabolic process; collagen catabolic process; proteolysis. Disease: Prolidase Deficiency

0.1 mL

255 USD