catalog number :
MBS9408000
products full name :
NTCP Polyclonal Antibody
products short name :
[NTCP]
products name syn :
[SLC10A1; NTCP; GIG29; Sodium/bile acid cotransporter; Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1]
other names :
[sodium/bile acid cotransporter; Sodium/bile acid cotransporter; sodium/bile acid cotransporter; solute carrier family 10 (sodium/bile acid cotransporter), member 1; Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1]
products gene name :
[NTCP]
other gene names :
[SLC10A1; SLC10A1; NTCP; NTCP]
uniprot entry name :
NTCP_HUMAN
specificity :
NTCP Polyclonal Antibody detects endogenous levels of NTCP protein.
purity :
IgG purity is >90% by SDS-PAGE.
form :
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
storage stability :
Store at -20 degree C/1 year
tested application :
Western Blot (WB), ELISA (EIA)
app notes :
ELISA: > or = 1: 1000. Western Blot: > or = 1: 500
image1 heading :
Western Blot (WB)
other info1 :
Immunogen Type: peptide. Immunogen Description: Synthesized peptide derived from the C-terminal region of human NTCP.
other info2 :
Target Name: NTCP
products categories :
Total protein Ab
ncbi acc num :
NP_003040.1
ncbi gb acc num :
NM_003049.3
ncbi pathways :
Bile Acid And Bile Salt Metabolism Pathway (1270040); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Drug Induction Of Bile Acid Pathway (698755); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Recycling Of Bile Acids And Salts Pathway (1270045)
ncbi summary :
The protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
uniprot summary :
NTCP: The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter. Chromosomal Location of Human Ortholog: 14q24.1. Cellular Component: integral to plasma membrane; basolateral plasma membrane; plasma membrane. Molecular Function: bile acid:sodium symporter activity. Biological Process: bile acid and bile salt transport; bile acid metabolic process; transport; sodium ion transport; transmembrane transport