antibody

C-Fos Antibody

MBS9407992

0.05 mL

200 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

C-Fos Antibody

[C-Fos]

[p55; AP-1]

[proto-oncogene c-Fos; Proto-oncogene c-Fos; proto-oncogene c-Fos; FBJ murine osteosarcoma viral oncogene homolog; Cellular oncogene fos; G0/G1 switch regulatory protein 7]

[C-Fos]

[FOS; FOS; p55; AP-1; C-FOS; G0S7]

FOS_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

380

The antibody detects endogenous level of total C-Fos protein.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0 mg/ml

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Western Blot (WB)

Western blotting: 1:500~1:1000

Western Blot (WB)

Immunogen Type: Peptide-KLH. Immunogen Description: Peptide sequence around aa.28~32(S-Y-Y-H-S) derived from Human C-Fos. Predicted MW: 62kD

Target Name: C-Fos

Total protein Ab

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.

4885241

NP_005243.1

NM_005252.3

P01100

ATF-2 Transcription Factor Network Pathway (138006); Activated TLR4 Signalling Pathway (1269236); Activation Of The AP-1 Family Of Transcription Factors Pathway (1269218); Amphetamine Addiction Pathway (547607); Amphetamine Addiction Pathway (550546); Apoptosis Modulation And Signaling Pathway (198822); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); BDNF Signaling Pathway (712093)

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008]

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

0.05 mL

200 USD

0.1 mL

255