antibody

CYP51A1 antibody

MBS9407979

0.1 mL

255 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunocytochemistry

Antibody

CYP51A1 antibody

[CYP51A1]

[LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM]

[lanosterol 14-alpha demethylase isoform 1; Lanosterol 14-alpha demethylase; lanosterol 14-alpha demethylase; cytochrome P450, family 51, subfamily A, polypeptide 1; CYPLI; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Sterol 14-alpha demethylase]

[CYP51A1]

[CYP51A1; CYP51A1; LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM; CYP51; LDM; Cytochrome P45014DM]

CP51A_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

509

The antibody detects endogenous level of total CYP51A1 antibody.

Antibodies were purified by affinity purification using immunogen.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0 mg/ml

Store at -20 degree C

Western Blot (WB), Immunofluorescence (IF)

Western blotting: 1:500 - 1:2000. Immunofluorescence: 1:20 - 1:100

Western Blot (WB)

Immunofluorescence (IF)

Immunogen Type: Recombinant Protein. Immunogen Description: Recombinant protein of human CYP51A1.

Target Name: CYP51A1

Total protein Ab

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene.

4503243

NP_000777.1

NM_000786.3

Q16850

SDS-PAGE MW: 56kd

Activation Of Gene Expression By SREBF (SREBP) Pathway (1270039); Biological Oxidations Pathway (1270189); Biosynthesis Of Antibiotics Pathway (1144997); Cholesterol Biosynthesis Pathway (198809); Cholesterol Biosynthesis Pathway (1270037); Cholesterol Biosynthesis, Squalene 2,3-epoxide = Cholesterol Pathway (413390); Cholesterol Biosynthesis, Squalene 2,3-epoxide = Cholesterol Pathway (468282); Cytochrome P450 - Arranged By Substrate Type Pathway (1270191); Endogenous Sterols Pathway (1270192); Metabolic Pathways (132956)

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

CYP51A1: Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4 -dimethyl cholesta-8,14,24-triene-3-beta-ol. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.14.13.70; Membrane protein, integral; Lipid Metabolism - steroid biosynthesis; Oxidoreductase. Chromosomal Location of Human Ortholog: 7q21.2. Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane. Molecular Function: sterol 14-demethylase activity; iron ion binding; heme binding. Biological Process: xenobiotic metabolic process; cholesterol biosynthetic process; steroid biosynthetic process; sterol metabolic process; cholesterol biosynthetic process via 24,25-dihydrolanosterol

0.1 mL

255 USD