product summary
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company name :
MyBioSource
product type :
antibody
product name :
SPHK2 Antibody
catalog :
MBS9407679
quantity :
0.1 mL
price :
255 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry
more info or order :
image
image 1 :
Gel: 8%SDS-PAGE . Lysates (from left to right): Mouse brain and liver tissue. Amount of lysate: 40ug per lane . Primary antibody: 1/200 dilution. Secondary antibody dilution: 1/8000 . Exposure time: 5 minutes
image 2 :
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using MBS9407679 at dilution 1/60.
product information
catalog number :
MBS9407679
products type :
Antibody
products full name :
SPHK2 Antibody
products short name :
[SPHK2]
products name syn :
[SK 2; SK-2; SPK 2; SPK-2]
other names :
[sphingosine kinase 2 isoform b; Sphingosine kinase 2; sphingosine kinase 2; sphingosine kinase 2]
products gene name :
[SPHK2]
other gene names :
[SPHK2; SPHK2; SK 2; SK-2; SPK 2; SPK-2; SK 2; SPK 2]
uniprot entry name :
SPHK2_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
595
specificity :
The antibody detects endogenous levels of total SPHK2 protein.
purity :
Antigen affinity purification.
form :
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
concentration :
2.2 mg/ml
storage stability :
Store at -20 degree C
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Western blotting: 1:200-1:1000. Immunohistochemistry: 1:25-1:100
image1 heading :
Testing Data
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen Type: Recombinant Protein. Immunogen Description: Fusion protein corresponding to residues near the C terminal of human sphingosine kinase 2
other info2 :
Target Name: SPHK2
products categories :
Total protein Ab
products description :
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ncbi gi num :
323462183
ncbi acc num :
NP_001191087.1
ncbi gb acc num :
NM_001204158.2
uniprot acc num :
Q9NRA0
ncbi mol weight :
SDS-PAGE MW: 69kd
ncbi pathways :
Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Ceramide Signaling Pathway (138023); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); IL12-mediated Signaling Events Pathway (137922); Metabolic Pathways (132956); Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); Signal Transduction Of S1P Receptor Pathway (198819)
ncbi summary :
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
uniprot summary :
SPHK2: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.7.1.91; Lipid Metabolism - sphingolipid; Kinase, lipid. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: membrane; lysosomal membrane; cytosol. Molecular Function: D-erythro-sphingosine kinase activity; protein binding; Ras GTPase binding; sphinganine kinase activity; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity. Biological Process: cell proliferation; blood vessel development; sphingolipid metabolic process; sphingolipid biosynthetic process; protein kinase C activation; positive regulation of cell proliferation; sphinganine-1-phosphate biosynthetic process; brain development; sphingosine metabolic process; lipid phosphorylation; negative regulation of apoptosis
size1 :
0.1 mL
price1 :
255 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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