antibody

AKAP13 Antibody

MBS9407536

0.1 mL

320 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

AKAP13 Antibody

AKAP13

AKAP13 protein, partial; A-kinase anchor protein 13; A-kinase anchor protein 13; A kinase (PRKA) anchor protein 13; AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein 31; Lymphoid blast crisis oncogene; LBC oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; Protein kinase A-anchoring protein 13; PRKA13; p47

AKAP13

AKAP13; AKAP13; BRX; LBC; p47; HA-3; Ht31; c-lbc; PRKA13; AKAP-13; AKAP-Lbc; ARHGEF13; PROTO-LB; PROTO-LBC; BRX; HT31; LBC; AKAP-13; LBC oncogene; PRKA13

AKP13_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

1085

Affinity purified

PBS, pH 7.4 with 0.02% Sodium Azide

1.0 mg/ml

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

ELISA (EIA), Western Blot (WB)

Target Name: AKAP13

Total protein Ab

229597179

AAI40863.1

19,992 Da

Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (1269447); G Protein Signaling Pathways (198849); G Alpha (12/13) Signalling Events Pathway (1269579); GPCR Downstream Signaling Pathway (1269574); NRAGE Signals Death Through JNK Pathway (1269448); Regulation Of RhoA Activity Pathway (138070); Rho GTPase Cycle Pathway (1269508); Signal Transduction Pathway (1269379); Signaling By GPCR Pathway (1269543); Signaling By Rho GTPases Pathway (1269507)

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]

AKAP13: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. 4 isoforms of the human protein are produced by alternative splicing. Protein type: GEFs, Rac/Rho; Adaptor/scaffold; Nuclear export; GEFs; Oncoprotein; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 15q24-q25. Cellular Component: membrane; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol. Molecular Function: protein binding; signal transducer activity; Rho guanyl-nucleotide exchange factor activity; Rho GTPase binding; cAMP-dependent protein kinase activity; metal ion binding; protein kinase A binding; protein complex scaffold. Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; nuclear export; regulation of protein kinase activity; protein amino acid phosphorylation

0.1 mL

320 USD