P-Selectin Polyclonal Antibody | MyBioSource MBS9407197 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

P-Selectin Polyclonal Antibody

catalog :

MBS9407197

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of 3T3 cells using P-Selectin Polyclonal Antibody

image 2 :

Western Blot analysis of NIH-3T3 KB cells using P-Selectin Polyclonal Antibody

product information

catalog number :

MBS9407197

products type :

Antibody

products full name :

P-Selectin Polyclonal Antibody

products short name :

[P-Selectin]

products name syn :

[SELP; GMRP; GRMP; P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P]

other names :

[P-selectin; P-selectin; P-selectin; selectin P (granule membrane protein 140kDa, antigen CD62); CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD_antigen: CD62P]

products gene name :

[P-Selectin]

other gene names :

[SELP; SELP; CD62; GRMP; PSEL; CD62P; GMP140; LECAM3; PADGEM; GMRP; GRMP; GMP-140; LECAM3; PADGEM]

uniprot entry name :

LYAM3_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

830

specificity :

P-Selectin Polyclonal Antibody detects endogenous levels of P-Selectin protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Store at -20°C/1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

Western Blot: 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

other info1 :

Immunogen Type: peptide. Immunogen Description: Synthesized peptide derived from the N-terminal region of human P-Selectin. SDS-PAGE MW: 91kD

other info2 :

Target Name: P-Selectin

products categories :

Total protein Ab

ncbi gi num :

157419154

ncbi acc num :

NP_002996.2

ncbi gb acc num :

NM_003005.3

uniprot acc num :

P16109

ncbi pathways :

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Hemostasis Pathway (1269340); IL-3 Signaling Pathway (198881); IL4-mediated Signaling Events Pathway (137933); Malaria Pathway (152665); Malaria Pathway (152657); Platelet Activation, Signaling And Aggregation Pathway (1269350); Platelet Degranulation Pathway (1269367)

ncbi summary :

This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]

uniprot summary :

SELP: Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Belongs to the selectin/LECAM family. Protein type: Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q22-q25. Cellular Component: nucleoplasm; extracellular space; platelet alpha granule membrane; integral to plasma membrane; cytoplasm; plasma membrane; platelet dense granule membrane; external side of plasma membrane. Molecular Function: heparin binding; protein binding; lipopolysaccharide binding; glycoprotein binding; glycosphingolipid binding; calcium-dependent protein binding; sialic acid binding; fucose binding. Biological Process: platelet activation; positive regulation of leukocyte migration; response to lipopolysaccharide; defense response to Gram-negative bacterium; heterophilic cell adhesion; positive regulation of phosphoinositide 3-kinase cascade; leukocyte adhesion; platelet degranulation; regulation of integrin activation; blood coagulation; leukocyte tethering or rolling; inflammatory response; cell adhesion; leukocyte migration. Disease: Ige Responsiveness, Atopic

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

255

more info or order :

MyBioSource product webpage