catalog number :
MBS9407158
products full name :
ASGR2 Antibody
products short name :
[ASGR2]
other names :
[asialoglycoprotein receptor 2 isoform a; Asialoglycoprotein receptor 2; asialoglycoprotein receptor 2; asialoglycoprotein receptor 2; Hepatic lectin 2; HL-2; mHL-2]
products gene name :
[ASGR2]
other gene names :
[Asgr2; Asgr2; Asgr; HL-2; ASGPR2; Asgr-2; Asgr-2; ASGP-R 2; ASGPR 2; HL-2; mHL-2]
uniprot entry name :
ASGR2_MOUSE
reactivity :
Human, Mouse, Rat
purity :
Affinity purified
form :
PBS, pH 7.4 with 0.02% sodium azide.
concentration :
1.0 mg/ml
storage stability :
This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing.
tested application :
ELISA (EIA), Immunohistochemistry (IHC)
app notes :
ELISA: 1:20000-1:80000. IHC: 1:100-1:500
image1 heading :
Testing Data
other info1 :
Immunogen Type: Recombinant Protein. Immunogen Description: Rabbit polyclonal ASGR2 (1) antibody was raised against a recombinate human ASGR2 protein 106-286aa (BC017251).
other info2 :
Target Name: ASGR2
products categories :
Total protein Ab
ncbi acc num :
NP_001300854.1
ncbi gb acc num :
NM_001313925.1
ncbi pathways :
Thyroid Hormone Synthesis Pathway (835432); Thyroid Hormone Synthesis Pathway (839541)
ncbi summary :
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Sep 2015]
uniprot summary :
ASGP-R: cell surface receptor that mediates the endocytosis of plasma glycoproteins in which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. It transports these glycoproteins via a series of membrane vesicles and tubules to an acidic-sorting organelle where the receptor and ligand dissociates. Then the receptor is recycled back to the cell surface. There are four alternatively spliced transcript variants of this gene. Protein type: Receptor, misc.; Membrane protein, integral. Cellular Component: membrane; integral to membrane. Molecular Function: carbohydrate binding. Biological Process: glycoprotein metabolic process; lipid homeostasis; regulation of protein stability; endocytosis