product summary
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company name :
MyBioSource
product type :
antibody
product name :
ANO1 Antibody
catalog :
MBS9406955
quantity :
0.1 mL
price :
225 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS9406955
products type :
Antibody
products full name :
ANO1 Antibody
products short name :
ANO1
products name syn :
DOG1; TAOS2; ORAOV2; TMEM16A
other names :
anoctamin-1; Anoctamin-1; anoctamin-1; anoctamin 1, calcium activated chloride channel; Discovered on gastrointestinal stromal tumors protein 1; Oral cancer overexpressed protein 2; Transmembrane protein 16A; Tumor-amplified and overexpressed sequence 2
products gene name :
ANO1
other gene names :
ANO1; ANO1; DOG1; TAOS2; ORAOV2; TMEM16A; DOG1; ORAOV2; TAOS2; TMEM16A
uniprot entry name :
ANO1_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
986
specificity :
The antibody detects endogenous levels of total ANO1 protein.
purity :
Antigen affinity purification.
form :
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
concentration :
2 mg/ml
storage stability :
Store at -20 degree C
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Western blotting: 1:200-1:1000. Immunohistochemistry: 1:25-1:100
other info1 :
Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human anoctamin 1, calcium activated chloride channel. Acession No: Swiss-Prot#: Q5XXA6NCBI. Gene ID: 55107. Gene Accession: NP_060513
other info2 :
Target Name: ANO1
products categories :
Total protein Ab
products description :
TMEM16A, also known as DOG1, ORAOV2, TAOS2 or ANO1 (anoctamin 1), is a 986 amino acid multi-pass membrane protein that localizes to both the cell membrane and the cytoplasm and belongs to the anoctamin family. Expressed in a variety of tissues with highest expression in skeletal muscle and liver, TMEM16A functions as a calcium-activated chloride channel that is required for normal tracheal development. Human TMEM16A shares 90% sequence identity with its mouse counterpart, suggesting a conserved role between species. TMEM16A is present in breast, pancreatic, gastric, and uterine cancers, as well as in neck, ovarian and parathyroid tumors, suggesting a role for TMEM16A in carcinogenesis. Three isoforms of TMEM16A exist due to alternative splicing events.
ncbi gi num :
194306539
ncbi acc num :
NP_060513.5
ncbi gb acc num :
NM_018043.5
uniprot acc num :
Q5XXA6
ncbi mol weight :
SDS-PAGE MW: 114kd
ncbi pathways :
Ion Channel Transport Pathway (1269950); Stimuli-sensing Channels Pathway (1269953); Transmembrane Transport Of Small Molecules Pathway (1269903)
uniprot summary :
ANO1: Acts as a calcium-activated chloride channel. Required for normal tracheal development. Belongs to the anoctamin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel; Transporter. Chromosomal Location of Human Ortholog: 11q13.3. Cellular Component: apical plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane. Molecular Function: protein binding; protein homodimerization activity; intracellular calcium activated chloride channel activity; protein heterodimerization activity; calcium activated cation channel activity. Biological Process: regulation of membrane potential; multicellular organismal development; chloride transport; transmembrane transport; cation transport
size1 :
0.1 mL
price1 :
225 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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