SHP-1 (Phospho-Tyr536) Antibody | MyBioSource MBS9406467 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SHP-1 (Phospho-Tyr536) Antibody

catalog :

MBS9406467

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using SHP-1(Phospho-Tyr536) Antibody (left) or the same antibody preincubated with blocking peptide(right).

image 2 :

Immunofluorescence staining of methanol-fixed Hela cells using SHP-1(Phospho-Tyr536) Antibody.

product information

catalog number :

MBS9406467

products type :

Antibody

products full name :

SHP-1 (Phospho-Tyr536) Antibody

products short name :

[SHP-1]

products name syn :

[70Z-SHP; HCP; HCPH; Hematopoietic cell protein-tyrosine phosphatase; PTN6]

other names :

[tyrosine-protein phosphatase non-receptor type 6 isoform 1; Tyrosine-protein phosphatase non-receptor type 6; tyrosine-protein phosphatase non-receptor type 6; protein tyrosine phosphatase, non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1]

products gene name :

[SHP-1]

other gene names :

[PTPN6; PTPN6; HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1; HCP; PTP1C; PTP-1C]

uniprot entry name :

PTN6_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

595

specificity :

The antibody detects endogenous level of SHP-1 only when phosphorylated at tyrosine 536.

form :

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1.0 mg/ml

storage stability :

Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.

tested application :

Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

Immunohistochemistry: 1:50~1:100. Immunofluorescence: 1:100~1:200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunofluorescence (IF)

other info1 :

Immunogen Type: Peptide-KLH. Immunogen Description: Peptide sequence around phosphorylation site of tyrosine 536 (S-E-Y(p)-G-N) derived from Human SHP-1. Modification: Phospho. Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

other info2 :

Modification: Phospho-Tyr536. Target Name: SHP-1

products categories :

Phospho-specific Ab

products description :

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus.

ncbi gi num :

18104989

ncbi acc num :

NP_002822.2

ncbi gb acc num :

NM_002831.5

uniprot acc num :

P29350

ncbi mol weight :

Predicted: 68 kd

ncbi pathways :

Adaptive Immune System Pathway (1269171); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (1269184); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); CXCR4-mediated Signaling Events Pathway (137910); Cell Surface Interactions At The Vascular Wall Pathway (1269373)

ncbi summary :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

255

more info or order :

MyBioSource product webpage