Factor XIII B Polyclonal Antibody | MyBioSource MBS9406236 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Factor XIII B Polyclonal Antibody

catalog :

MBS9406236

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of COLO cells using Factor XIII B Polyclonal Antibody

product information

catalog number :

MBS9406236

products type :

Antibody

products full name :

Factor XIII B Polyclonal Antibody

products short name :

[Factor XIII B]

products name syn :

[F13B; Coagulation factor XIII B chain; Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain]

other names :

[coagulation factor XIII B chain; Coagulation factor XIII B chain; coagulation factor XIII B chain; coagulation factor XIII, B polypeptide; Fibrin-stabilizing factor B subunit; Protein-glutamine gamma-glutamyltransferase B chain; Transglutaminase B chain]

other gene names :

[F13B; F13B; FXIIIB]

uniprot entry name :

F13B_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

661

specificity :

Factor XIII B Polyclonal Antibody detects endogenous levels of Factor XIII B protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Store at -20 degree C/1 year

tested application :

Immunohistochemistry (IHC), Immunfluorescence (IF), ELISA (EIA), Western Blot (WB)

app notes :

Western Blot 1:500-2000!!Immunohistochemistry: 1:100 - 1:300. Immunofluorescence: 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

image1 heading :

Western Blot (WB)

other info1 :

Immunogen Type: peptide. Immunogen Description: Synthesized peptide derived from the N-terminal region of human Factor XIII B.

other info2 :

Target Name: Factor XIII B

products categories :

Total protein Ab

ncbi gi num :

110611237

ncbi acc num :

NP_001985.2

ncbi gb acc num :

NM_001994.2

uniprot acc num :

P05160

ncbi mol weight :

125kd

ncbi pathways :

Blood Clotting Cascade Pathway (198840); Common Pathway Of Fibrin Clot Formation (1269371); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Formation Of Fibrin Clot (Clotting Cascade) Pathway (1269368); Hemostasis Pathway (1269340); Prostate Cancer Pathway (755440); Steroid Biosynthesis Pathway (198866)

ncbi summary :

This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]

uniprot summary :

F13B: The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin. Defects in F13B are the cause of factor XIII subunit B deficiency (FA13BD). FA13BD is an autosomal recessive disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1q31-q32.1. Cellular Component: extracellular region. Biological Process: blood coagulation. Disease: Factor Xiii, B Subunit, Deficiency Of

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

255

more info or order :

MyBioSource product webpage