MTMR7 Antibody | MyBioSource MBS9406043 product information

product summary

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company name :

MyBioSource

product type :

antibody

product name :

MTMR7 Antibody

catalog :

MBS9406043

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.

image 2 :

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/40.

product information

catalog number :

MBS9406043

products type :

Antibody

products full name :

MTMR7 Antibody

products short name :

[MTMR7]

products name syn :

[DKFZp781E194; MGC163449; MGC163451]

other names :

[myotubularin-related protein 7; Myotubularin-related protein 7; myotubularin-related protein 7; myotubularin related protein 7]

products gene name :

[MTMR7]

other gene names :

[MTMR7; MTMR7]

uniprot entry name :

MTMR7_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

660

specificity :

The antibody detects endogenous levels of total MTMR7 protein.

purity :

Antigen affinity purification.

form :

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

concentration :

1.6 mg/ml

storage stability :

Store at -20 degree C

tested application :

Immunohistochemistry (IHC)

app notes :

Immunohistochemistry: 1:50-1:200

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Recombinant Protein. Immunogen Description: Fusion protein corresponding to residues near the C terminal of human myotubularin related protein 7

products categories :

Total protein Ab

products description :

This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5.

ncbi gi num :

225543474

ncbi acc num :

BC130579

ncbi gb acc num :

NM_004686.4

uniprot acc num :

Q9Y216

ncbi pathways :

Metabolism Pathway (1269956); Metabolism Of Lipids And Lipoproteins Pathway (1270001); PI Metabolism Pathway (1270073); Phospholipid Metabolism Pathway (1270053); Synthesis Of PIPs At The Late Endosome Membrane Pathway (1270082)

ncbi summary :

This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Mar 2009]

uniprot summary :

MTMR7: a protein of the myotubularin family. Myotubularins are a family of unique protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as physiological substrates. Myotubularins specifically dephosphorylate phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinositol 5-phosphate [PI(5)P], respectively. PI(3)P and PI(3,5)P2 regulate membrane trafficking events through the recruitment of effector proteins containing the lipid-binding domains FYVE, PH, and ENTH. MTMR5, -9, -10, -11, -12, -13 are catalytically inactive lipid phosphatases but may mediate important protein-protein interactions. Expressed at high levels in the brain. Two alternatively spliced human isoforms have been described. Protein type: Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.-; Phosphatase, lipid. Chromosomal Location of Human Ortholog: 8p22. Cellular Component: membrane; cytosol. Molecular Function: protein tyrosine phosphatase activity. Biological Process: phospholipid metabolic process; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage