antibody

Sodium Channel-pan Antibody

MBS9405344

0.05 mL

200 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

Sodium Channel-pan Antibody

[Sodium Channel-pan]

[CIN5; HH1; SCN5A; Sodium channel protein; cardiac muscle alpha-subunit]

[sodium channel protein type 5 subunit alpha isoform b; Sodium channel protein type 5 subunit alpha; sodium channel protein type 5 subunit alpha; sodium channel, voltage gated, type V alpha subunit; HH1; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein type V subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.5]

[SCN5A; SCN5A; HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5]

SCN5A_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

2015

The antibody detects endogenous levels of total sodium channel protein.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0 mg/ml

Store at -20 degree C

Western Blot (WB), Immunohistochemistry (IHC)

Western blotting: 1:500~1:3000. Immunohistochemistry: 1:50~1:100

Western Blot (WB)

Immunohistochemistry (IHC)

Immunogen Type: Peptide. Immunogen Description: Synthesized peptide derived from human sodium channel.

Target Name: Sodium Channel-pan

Total protein Ab

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.Sebastian K.G. Maier, Circulation, Mar 2004; 109: 1421 - 1427. T.R. Cummins, Neurology, Jan 2003; 60: 224 - 229. Christopher A. Ahern, Circ. Res., May 2005; 96: 991 - 998. Jyoti Dhar Malhotra, Circulation, Mar 2001; 103: 1303 - 1310.

30089970

NP_000326.2

NM_000335.4

Q14524

230kd (SDS-PAGE)

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Axon Guidance Pathway (1270303); Cardiac Progenitor Differentiation Pathway (712094); Developmental Biology Pathway (1270302); Interaction Between L1 And Ankyrins Pathway (1270325); L1CAM Interactions Pathway (1270323); SIDS Susceptibility Pathways (198901)

The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SCN5A: an integral membrane protein and a voltage-gated sodium channel subunit. Mediates the voltage-dependent sodium ion permeability of excitable membranes. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. Intracellular calcium levels regulate channel inactivation. Interacts with the PDZ domain of the syntrophin SNTA1, SNTB1 and SNTB2. Interacts with NEDD4, NEDD4L, WWP2 and GPD1L. Defects in this protein are a cause of long QT syndrome type 3 (LQT3). Belongs to the sodium channel (TC 1.A.1.10) family, Nav1.5/SCN5A subfamily. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Channel, sodium; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 3p21. Cellular Component: voltage-gated sodium channel complex; cell surface; endoplasmic reticulum; T-tubule; plasma membrane; integral to membrane; caveola; lateral plasma membrane; sarcolemma. Molecular Function: calmodulin binding; protein binding; fibroblast growth factor binding; enzyme binding; ubiquitin protein ligase binding; voltage-gated sodium channel activity; ankyrin binding; nitric-oxide synthase binding; protein kinase binding. Biological Process: axon guidance; membrane depolarization; telencephalon development; regulation of heart rate; sodium ion transport; generation of action potential; cerebellum development; response to denervation involved in regulation of muscle adaptation; positive regulation of action potential; positive regulation of epithelial cell proliferation; cardiac muscle contraction; odontogenesis of dentine-containing teeth. Disease: Sudden Infant Death Syndrome; Brugada Syndrome 1; Ventricular Fibrillation During Myocardial Infarction, Susceptibility To; Sick Sinus Syndrome 1, Autosomal Recessive; Progressive Familial Heart Block, Type Ia; Long Qt Syndrome 3; Cardiomyopathy, Dilated, 1e; Atrial Fibrillation, Familial, 10

0.05 mL

200 USD

0.1 mL

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