Cleaved-PARP antibody | MyBioSource MBS9404799 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Cleaved-PARP antibody

catalog :

MBS9404799

quantity :

0.1 mL

price :

225 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9404799

products type :

Antibody

products full name :

Cleaved-PARP antibody

products short name :

Cleaved-PARP

products name syn :

ADP-ribosyltransferase 1; ADPRT; ADPRT1; pADPRT-1; PARP; PARP-1; poly (ADP-ribose) pol; poly [ADP-ribose] polymerase 1; poly[ADP-ribose] synthetase 1; PPOL

other names :

poly; Poly [ADP-ribose] polymerase 1; poly [ADP-ribose] polymerase 1; poly (ADP-ribose) polymerase 1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1

other gene names :

PARP1; PARP1; PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; ADPRT; PPOL; PARP-1; ARTD1; ADPRT 1

uniprot entry name :

PARP1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

1014

specificity :

PARP (Cleaved-Asp214) Antibody detects endogenous levels of fragment of activated PARP resulting from cleavage adjacent to Asp214.

purity :

Immunogen affinity purified

form :

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 degree C. Stable for 14 months from date of receipt.

concentration :

1.0 mg/ml

storage stability :

Store at -20 degree C/1 year

tested application :

Western Blot (WB)

app notes :

WB: 1:500-1:2000

other info2 :

Target Name: Cleaved-PARP

products categories :

Total protein Ab

products description :

Nvolved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

ncbi gi num :

156523968

ncbi acc num :

NP_001609.2

ncbi gb acc num :

NM_001618.3

uniprot acc num :

P09874

ncbi mol weight :

85,110KD

ncbi pathways :

BER Complex Pathway (413429); BER Complex Pathway (468377); Base Excision Repair Pathway (1270351); Base Excision Repair Pathway (83043); Base Excision Repair Pathway (451); Caspase Cascade In Apoptosis Pathway (137974); Corticotropin-releasing Hormone Pathway (920957); DNA Repair Pathway (1270350); Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway (1269529); FAS Pathway And Stress Induction Of HSP Regulation (198894)

ncbi summary :

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]

uniprot summary :

PARP1: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LRIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423. Interacts (when poly-ADP- ribosylated) with CHD1L. Interacts with the DNA polymerase alpha catalytic subunit POLA1; this interaction functions as part of the control of replication fork progression. Interacts with EEF1A1, RNF4 and TXK. Protein type: EC 2.4.2.30; Nuclear receptor co-regulator; Nuclear envelope; Nucleolus; Transferase; DNA repair, damage. Chromosomal Location of Human Ortholog: 1q41-q42. Cellular Component: nucleoplasm; transcription factor complex; membrane; nucleolus; nuclear envelope; nucleus. Molecular Function: identical protein binding; protein binding; enzyme binding; DNA binding; zinc ion binding; protein N-terminus binding; NAD binding; transcription factor binding; protein kinase binding; NAD+ ADP-ribosyltransferase activity. Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; macrophage differentiation; transcription, DNA-dependent; DNA damage response, detection of DNA damage; negative regulation of transcription from RNA polymerase II promoter; DNA repair; protein autoprocessing; protein amino acid ADP-ribosylation; cellular response to insulin stimulus; base-excision repair; double-strand break repair; transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; gene expression; regulation of growth rate; telomere maintenance

size1 :

0.1 mL

price1 :

225 USD

more info or order :

MyBioSource product webpage