IL23R Antibody | MyBioSource MBS9404638 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IL23R Antibody

catalog :

MBS9404638

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of various cell lines, using IL23R antibody.

image 2 :

Immunofluorescence analysis of MCF7 cell using IL23R antibody. Blue: DAPI for nuclear staining.

image 3 :

Immunohistochemistry of paraffin-embedded human kidney using IL23R antibody at dilution of 1:200 (x400 lens)

product information

catalog number :

MBS9404638

products type :

Antibody

products full name :

IL23R Antibody

products short name :

[IL23R]

other names :

[interleukin-23 receptor; Interleukin-23 receptor]

products gene name :

[IL23R]

other gene names :

[IL23R; IL-23 receptor; IL-23R]

uniprot entry name :

IL23R_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

629

specificity :

The antibody detects endogenous level of total IL23R protein.

purity :

Antibodies were purified by affinity purification using immunogen.

form :

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1.0 mg/ml

storage stability :

Store at -20°C

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

Western blotting: 1:500 - 1:2000. Immunohistochemistry: 1:50 - 1:100. Immunofluorescence: 1:50 - 1:200

image1 heading :

Western Blot (WB)

image2 heading :

Immunofluorescence (IF)

image3 heading :

Immunohistochemistry

other info1 :

Immunogen Type: Recombinant Protein. Immunogen Description: Recombinant protein of human IL23R. SDS-PAGE MW: 69kD

other info2 :

Target Name: IL23R

products categories :

Total protein Ab

products description :

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.

ncbi gi num :

24430212

ncbi acc num :

NP_653302.2

ncbi gb acc num :

NM_144701.2

uniprot acc num :

Q5VWK5

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL23-mediated Signaling Events Pathway (138000); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488)

uniprot summary :

IL23R: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7). Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Belongs to the type I cytokine receptor family. Type 2 subfamily. 7 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p31.3. Cellular Component: receptor complex. Molecular Function: interleukin-23 binding; interleukin-23 receptor activity; interleukin-12 receptor binding. Biological Process: positive regulation of interleukin-17 production; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of memory T cell differentiation; positive regulation of natural killer cell proliferation; positive regulation of NK T cell activation; negative regulation of interleukin-10 production; positive regulation of T-helper 1 type immune response; positive regulation of osteoclast differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of interleukin-12 production; positive regulation of tyrosine phosphorylation of Stat4 protein; response to lipopolysaccharide; defense response to Gram-negative bacterium; positive regulation of activated T cell proliferation; regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of T cell proliferation; inflammatory response; positive regulation of defense response to virus by host. Disease: Inflammatory Bowel Disease 17; Psoriasis 7, Susceptibility To

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage