Fatty Acid Synthase antibody | MyBioSource MBS9404421 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Fatty Acid Synthase antibody

catalog :

MBS9404421

quantity :

0.1 mL

price :

320 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Sample (30 ug of whole cell lysate)A: Molt-4 7.5% SDS PAGEPrimary antibody diluted at 1: 1000

image 2 :

Immunohistochemical analysis of paraffin-embedded OVCAR3 xenograft, using Fatty Acid Synthase antibody at 1: 500 dilution.

image 3 :

Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Fatty Acid Synthase antibody at 1: 200 dilution.

product information

catalog number :

MBS9404421

products type :

Antibody

products full name :

Fatty Acid Synthase antibody

products short name :

[Fatty Acid Synthase]

other names :

[fatty acid synthase; Fatty acid synthase; fatty acid synthase; fatty acid synthase]

other gene names :

[FASN; FASN; FAS; OA-519; SDR27X1; FAS]

uniprot entry name :

FAS_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

2511

purity :

Purified by antigen-affinity chromatography.

form :

Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.

concentration :

1 mg/ml

storage stability :

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

Western blotting: 1:500-1:3000. Immunohistochemistry: 1:100-1:500. Immunofluorescence: 1:100-1:200

image1 heading :

Testing Data

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunofluorescence (IF)

other info1 :

Immunogen Type: Recombinant protein. Immunogen Description: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 7 and 257 of Fatty Acid Synthase. Predicted MW: 273kD

other info2 :

Target Name: Fatty Acid Synthase

products categories :

Total protein Ab

products description :

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq]

ncbi gi num :

41872631

ncbi acc num :

NP_004095

ncbi gb acc num :

NM_004104.4

ncbi pathways :

AMPK Signaling Pathway (198868); AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Activation Of Gene Expression By SREBF (SREBP) Pathway (1270039); ChREBP Activates Metabolic Gene Expression Pathway (1270114); Fatty Acid Biosynthesis Pathway (198873); Fatty Acyl-CoA Biosynthesis Pathway (1270012); Fatty Acid Biosynthesis Pathway (82933); Fatty Acid Biosynthesis Pathway (294); Fatty Acid Biosynthesis, Elongation Pathway (413379)

ncbi summary :

uniprot summary :

FASN: a multifunctional enzyme. Catalyzes the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. Protein type: Oxidoreductase; EC 1.1.1.100; EC 3.1.2.14; EC 1.3.1.39; EC 2.3.1.41; EC 2.3.1.85; Hydrolase; Acetyltransferase; EC 4.2.1.59; Lipid Metabolism - fatty acid biosynthesis; EC 2.3.1.39; Lyase; EC 2.3.1.38. Chromosomal Location of Human Ortholog: 17q25. Cellular Component: Golgi apparatus; glycogen granule; membrane; mitochondrion; cytoplasm; plasma membrane; melanosome; cytosol. Molecular Function: protein homodimerization activity; fatty-acid synthase activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; zinc ion binding; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; drug binding; [acyl-carrier-protein] S-acetyltransferase activity; 3-oxoacyl-[acyl-carrier-protein] reductase activity; protein binding; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; oleoyl-[acyl-carrier-protein] hydrolase activity; [acyl-carrier-protein] S-malonyltransferase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity. Biological Process: osteoblast differentiation; vitamin metabolic process; acetyl-CoA metabolic process; pantothenate metabolic process; positive regulation of cellular metabolic process; energy reserve metabolic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; fatty acid metabolic process; water-soluble vitamin metabolic process; fatty acid biosynthetic process

size1 :

0.1 mL

price1 :

320 USD

more info or order :

MyBioSource product webpage