Galpha t1 Polyclonal Antibody | MyBioSource MBS9404343 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Galpha t1 Polyclonal Antibody

catalog :

MBS9404343

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of COLO205 cells using Ga t1 Polyclonal Antibody

product information

catalog number :

MBS9404343

products type :

Antibody

products full name :

Galpha t1 Polyclonal Antibody

products short name :

[Galpha t1]

products name syn :

[GNAT1; GNATR; Guanine nucleotide-binding protein G(t) subunit alpha-1; Transducin alpha-1 chain]

other names :

[guanine nucleotide-binding protein G(t) subunit alpha-1; Guanine nucleotide-binding protein G(t) subunit alpha-1; guanine nucleotide-binding protein G(t) subunit alpha-1; guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1; Transducin alpha-1 chain]

products gene name :

[Galpha t1]

other gene names :

[GNAT1; GNAT1; GBT1; GNATR; CSNB1G; CSNBAD3; GNATR]

uniprot entry name :

GNAT1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

350

specificity :

Ga t1 Polyclonal Antibody detects endogenous levels of Ga t1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Store at -20 degree C/1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

Western Blot: 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

image1 heading :

Western Blot (WB)

other info1 :

Immunogen Type: peptide. Immunogen Description: Synthesized peptide derived from the Internal region of human Ga t1.

other info2 :

Target Name: Ga t1

products categories :

Total protein Ab

ncbi gi num :

22027520

ncbi acc num :

NP_000163.2

ncbi gb acc num :

NM_000172.3

uniprot acc num :

P11488

ncbi mol weight :

36kd by SDS-PAGE

ncbi pathways :

Activation Of The Phototransduction Cascade Pathway (1269628); G Alpha (i) Signalling Events Pathway (1269576); G-protein Activation Pathway (1269585); G-protein Mediated Events Pathway (1269586); GPCR Downstream Signaling Pathway (1269574); Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway (1269629); Opioid Signalling Pathway (1269584); PLC Beta Mediated Events Pathway (1269587); Phototransduction Pathway (149806); Phototransduction Pathway (148660)

ncbi summary :

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

uniprot summary :

G-alpha t1: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Defects in GNAT1 are the cause of congenital stationary night blindness autosomal dominant type 3 (CSNBAD3); also known as congenital stationary night blindness Nougaret type. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Protein type: G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G((i/o/t/z)). Chromosomal Location of Human Ortholog: 3p21. Cellular Component: photoreceptor inner segment; photoreceptor outer segment; cell soma; membrane; apical plasma membrane; plasma membrane; heterotrimeric G-protein complex; cytosol; photoreceptor connecting cilium. Molecular Function: GTPase activity; signal transducer activity; acyl binding; GDP binding; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; protein kinase binding. Biological Process: phototransduction, visible light; response to light stimulus; sensory perception of umami taste; metabolic process; response to light intensity; detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; rhodopsin mediated signaling; G-protein signaling, coupled to cAMP nucleotide second messenger; cell proliferation; eye photoreceptor cell development; regulation of rhodopsin mediated signaling; visual perception; retina development in camera-type eye; detection of light stimulus involved in visual perception; positive regulation of cyclic-nucleotide phosphodiesterase activity; negative regulation of cyclic-nucleotide phosphodiesterase activity. Disease: Night Blindness, Congenital Stationary, Type 1g; Night Blindness, Congenital Stationary, Autosomal Dominant 3

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

255

more info or order :

MyBioSource product webpage