antibody

CHI3L1 antibody

MBS9404305

0.1 mL

255 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

Antibody

CHI3L1 antibody

[CHI3L1]

[ASRT7; DKFZp686N19119; FLJ38139; GP39; HC-gp39; HCGP-3P; YKL40; YYL-40]

[chitinase-3-like protein 1; Chitinase-3-like protein 1; chitinase-3-like protein 1; chitinase 3-like 1 (cartilage glycoprotein-39); 39 kDa synovial protein; Cartilage glycoprotein 39; CGP-39; GP-39; hCGP-39; YKL-40]

[CHI3L1]

[CHI3L1; CHI3L1; GP39; ASRT7; GP-39; YKL40; CGP-39; YKL-40; YYL-40; HC-gp39; HCGP-3P; hCGP-39; CGP-39; GP-39; hCGP-39]

CH3L1_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

383

The antibody detects endogenous level of total CHI3L1 antibody.

Antibodies were purified by affinity purification using immunogen.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0 mg/ml

Store at -20 degree C

Western Blot (WB)

Western blotting: 1:500 - 1:2000

Western Blot (WB)

Immunogen Type: Recombinant Protein. Immunogen Description: Recombinant protein of human CHI3L1.

Target Name: CHI3L1

Total protein Ab

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

144226251

NP_001267.2

NM_001276.2

P36222

43kd

Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]

CHI3L1: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7). Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. Belongs to the glycosyl hydrolase 18 family. Protein type: Secreted, signal peptide; Cell adhesion; Secreted. Chromosomal Location of Human Ortholog: 1q32.1. Cellular Component: extracellular space; proteinaceous extracellular matrix; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm. Molecular Function: extracellular matrix structural constituent; chitin binding; chitinase activity; carbohydrate binding. Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; response to mechanical stimulus; apoptosis; cartilage development; carbohydrate metabolic process; activation of NF-kappaB-inducing kinase; immune response; chitin catabolic process; inflammatory response; lung development. Disease: Schizophrenia; Asthma-related Traits, Susceptibility To, 7

0.1 mL

255 USD