Collagen XVIII alpha1 Antibody | MyBioSource MBS9403746 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Collagen XVIII alpha1 Antibody

catalog :

MBS9403746

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using Collagen XVIII a1 antibody.

image 2 :

Immunofluorescence analysis of A549 cells, using Collagen XVIII a1 antibody.

product information

catalog number :

MBS9403746

products type :

Antibody

products full name :

Collagen XVIII alpha1 Antibody

products short name :

[Collagen XVIII alpha1]

products name syn :

[Collagen XVIII a1 Antibody; Collagen alpha-1(XVIII) chain; Endostatin; COIA1]

other names :

[collagen alpha-1(XVIII) chain isoform 1 preproprotein; Collagen alpha-1(XVIII) chain; collagen alpha-1(XVIII) chain; collagen, type XVIII, alpha 1]

other gene names :

[COL18A1; COL18A1; KS; KNO; KNO1]

uniprot entry name :

COIA1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

1516

specificity :

The antibody detects endogenous levels of total Collagen XVIII a1 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1.0 mg/ml

storage stability :

Store at -20 degree C

tested application :

Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

Immunohistochemistry: 1:50~1:100. Immunofluorescence: 1:100~1:500

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunofluorescence (IF)

other info1 :

Immunogen Type: Peptide. Immunogen Description: Synthesized peptide derived from internal of human Collagen XVIII a1.

other info2 :

Target Name: Collagen XVIII a1

products categories :

Total protein Ab

products description :

COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.Saarela J., Matrix Biol. 16:319-328(1998).Elamaa H., Matrix Biol. 22:427-442(2003).Hattori M, Nature 405:311-319(2000).

ncbi gi num :

110611235

ncbi acc num :

NP_085059.2

ncbi gb acc num :

NM_030582.3

uniprot acc num :

P39060

ncbi mol weight :

178kd

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (1270258); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1270247); Collagen Biosynthesis And Modifying Enzymes Pathway (1270246); Collagen Degradation Pathway (1270259); Collagen Formation Pathway (1270245); Degradation Of The Extracellular Matrix Pathway (1270257); Direct P53 Effectors Pathway (137939); Extracellular Matrix Organization Pathway (1270244); FOXA1 Transcription Factor Network Pathway (137979); Integrin Cell Surface Interactions Pathway (1270260)

ncbi summary :

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

uniprot summary :

COL18A1: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1). An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele. Belongs to the multiplexin collagen family. 3 isoforms of the human protein are produced by alternative promoter. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: extracellular matrix; extracellular space; collagen; endoplasmic reticulum lumen; extracellular region; basement membrane. Molecular Function: identical protein binding; protein binding; metal ion binding; structural molecule activity. Biological Process: response to drug; collagen catabolic process; extracellular matrix disassembly; negative regulation of cell proliferation; organ morphogenesis; extracellular matrix organization and biogenesis; visual perception; positive regulation of cell proliferation; endothelial cell morphogenesis; angiogenesis; cell adhesion; response to hydrostatic pressure; positive regulation of cell migration. Disease: Knobloch Syndrome 1

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

255

more info or order :

MyBioSource product webpage