ITGA6 Antibody | MyBioSource MBS9403415 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ITGA6 Antibody

catalog :

MBS9403415

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/50.

product information

catalog number :

MBS9403415

products type :

Antibody

products full name :

ITGA6 Antibody

products short name :

[ITGA6]

products name syn :

[CD49f; VLA-6; ITGA6B]

other names :

[integrin alpha-6 isoform b; Integrin alpha-6; integrin alpha-6; integrin, alpha 6; CD49 antigen-like family member F; VLA-6; CD_antigen: CD49f]

products gene name :

[ITGA6]

other gene names :

[ITGA6; ITGA6; CD49f; VLA-6; ITGA6B; Alpha6p]

uniprot entry name :

ITA6_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

1073

specificity :

The antibody detects endogenous levels of total ITGA6 protein.

purity :

Antigen affinity purification.

form :

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

concentration :

1.7 mg/ml

storage stability :

Store at -20 degree C

tested application :

Immunohistochemistry (IHC)

app notes :

Immunohistochemistry: 1:25-1:100

image1 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human integrin, alpha 6

other info2 :

Target Name: ITGA6

products categories :

Total protein Ab

products description :

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.

ncbi gi num :

119395742

ncbi acc num :

NP_000201.2

ncbi gb acc num :

NM_000210.2

uniprot acc num :

P23229

ncbi mol weight :

122,358 Da

ncbi pathways :

Alpha6-Beta4 Integrin Signaling Pathway (198807); Arf6 Trafficking Events Pathway (137954); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1270247); Basigin Interactions Pathway (1269376); CXCR4-mediated Signaling Events Pathway (137910); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480)

ncbi summary :

uniprot summary :

ITGA6: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Belongs to the integrin alpha chain family. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc. Chromosomal Location of Human Ortholog: 2q31.1. Cellular Component: cell surface; cell-cell adherens junction; focal adhesion; hemidesmosome; basal plasma membrane; plasma membrane; basement membrane; filopodium; external side of plasma membrane. Molecular Function: integrin binding; protein binding; metal ion binding; laminin binding. Biological Process: skin development; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; filopodium formation; positive regulation of apoptosis; cell-matrix adhesion; cell-substrate adhesion; hemidesmosome assembly; cell-cell adhesion; gut development; positive regulation of cell-cell adhesion; cell-substrate junction assembly; brown fat cell differentiation; cellular response to extracellular stimulus; cell adhesion mediated by integrin; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; leukocyte migration; positive regulation of phosphorylation. Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage