ACOX1 Antibody | MyBioSource MBS9403251 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ACOX1 Antibody

catalog :

MBS9403251

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Gel: 8%SDS-PAGE Lysates (from left to right): Mouse stomach, liver and kidney tissue Amount of lysate: 40ug per lane Primary antibody: 1/350 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute

image 2 :

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/20.

product information

catalog number :

MBS9403251

products type :

Antibody

products full name :

ACOX1 Antibody

products short name :

[ACOX1]

products name syn :

[ACOX; SCOX; PALMCOX]

other names :

[peroxisomal acyl-coenzyme A oxidase 1 isoform c; Peroxisomal acyl-coenzyme A oxidase 1; peroxisomal acyl-coenzyme A oxidase 1; acyl-CoA oxidase 1, palmitoyl; Palmitoyl-CoA oxidase; Straight-chain acyl-CoA oxidase; SCOX]

products gene name :

[ACOX1]

other gene names :

[ACOX1; ACOX1; ACOX; SCOX; PALMCOX; ACOX; AOX; SCOX]

uniprot entry name :

ACOX1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

622

specificity :

The antibody detects endogenous levels of total ACOX1 protein.

purity :

Antigen affinity purification.

form :

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

concentration :

0.8 mg/ml

storage stability :

Store at -20 degree C

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Western blotting: 1:200-1:1000. Immunohistochemistry: 1:15-1:50

image1 heading :

Testing Data

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Recombinant Protein. Immunogen Description: Fusion protein corresponding to residues near the C terminal of human Acyl-CoA oxidase 1, palmitoyl

other info2 :

Target Name: ACOX1

products categories :

Total protein Ab

products description :

The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.

ncbi gi num :

297206874

ncbi acc num :

NP_001171968.1

ncbi gb acc num :

NM_001185039.1

uniprot acc num :

Q15067

ncbi mol weight :

74kd

ncbi pathways :

Beta-oxidation Of Very Long Chain Fatty Acids Pathway (1270034); Biosynthesis Of Unsaturated Fatty Acids Pathway (83034); Biosynthesis Of Unsaturated Fatty Acids Pathway (429); Fatty Acid Degradation Pathway (82935); Fatty Acid Degradation Pathway (296); Fatty Acid Metabolism Pathway (868084); Fatty Acid Metabolism Pathway (878045); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (1270010); Metabolic Pathways (132956); Metabolism Pathway (1269956)

ncbi summary :

uniprot summary :

ACOX1: Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy- palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl- CoA. Defects in ACOX1 are the cause of adrenoleukodystrophy pseudoneonatal (Pseudo-NALD); also known as peroxisomal acyl-CoA oxidase deficiency. Pseudo-NALD is a peroxisomal single-enzyme disorder. Clinical features include mental retardation, leukodystrophy, seizures, mild hepatomegaly, hearing deficit. Pseudo-NALD is characterized by increased plasma levels of very-long chain fatty cids, due to decreased or absent peroxisome acyl-CoA oxidase activity. Peroxisomes are intact and functioning. Belongs to the acyl-CoA oxidase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; Lipid Metabolism - alpha-linolenic acid; EC 1.3.3.6; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lipid Metabolism - fatty acid. Chromosomal Location of Human Ortholog: 17q25.1. Cellular Component: nucleoplasm; peroxisomal membrane; peroxisomal matrix; membrane; mitochondrion; intracellular membrane-bound organelle; plasma membrane; nucleolus; peroxisome; nucleus. Molecular Function: palmitoyl-CoA oxidase activity; acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; FAD binding; protein N-terminus binding; fatty acid binding; receptor binding; PDZ domain binding. Biological Process: peroxisome fission; generation of precursor metabolites and energy; fatty acid beta-oxidation using acyl-CoA oxidase; very-long-chain fatty acid metabolic process; unsaturated fatty acid metabolic process; lipid homeostasis; spermatogenesis; fatty acid oxidation; lipid metabolic process; cellular lipid metabolic process; prostaglandin metabolic process. Disease: Peroxisomal Acyl-coa Oxidase Deficiency

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage