product summary
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company name :
MyBioSource
product type :
antibody
product name :
POU6F2 Antibody
catalog :
MBS9402684
quantity :
0.1 mL
price :
255 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry
more info or order :
image
image 1 :
Gel: 6%SDS-PAGE Lysates (from left to right): Mouse heart tissue. Amount of lysate: 40ug per lane . Primary antibody: 1/200 dilution . Secondary antibody dilution: 1/8000 . Exposure time: 30 seconds
image 2 :
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30.
product information
catalog number :
MBS9402684
products type :
Antibody
products full name :
POU6F2 Antibody
products short name :
[POU6F2]
products name syn :
[WT5; WTSL; RPF-1]
other names :
[POU domain, class 6, transcription factor 2 isoform 2; POU domain, class 6, transcription factor 2; POU domain, class 6, transcription factor 2; POU class 6 homeobox 2; Retina-derived POU domain factor 1; RPF-1]
products gene name :
[POU6F2]
other gene names :
[POU6F2; POU6F2; WT5; WTSL; RPF-1; RPF1; RPF-1]
uniprot entry name :
PO6F2_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse
sequence length :
655
specificity :
The antibody detects endogenous levels of total POU6F2 protein.
purity :
Antigen affinity purification.
form :
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
concentration :
1.9 mg/ml
storage stability :
Store at -20°C
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Western blotting: 1:200-1:1000. Immunohistochemistry: 1:50-1:200
image1 heading :
Testing Data
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human POU class 6 homeobox 2
other info2 :
Target Name: POU6F2
products categories :
Total protein Ab
products description :
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition.
ncbi gi num :
260436858
ncbi acc num :
NP_001159490/P78424
ncbi gb acc num :
NM_001166018.1
uniprot acc num :
P78424
ncbi mol weight :
73kd by SDS-PAGE
ncbi summary :
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
uniprot summary :
POU6F2: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5 -ATGCAAAT-3 . Isoform 1 does not bind DNA. Defects in POU6F2 are a cause of hereditary susceptibility to Wilms tumor 5 (WT5). WT5 is a pediatric malignancy of kidney and one of the most common solid cancers in childhood. Belongs to the POU transcription factor family. Class- 6 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transcription factor; Cell development/differentiation; DNA-binding. Chromosomal Location of Human Ortholog: 7p14.1. Cellular Component: nucleus. Molecular Function: DNA binding; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; central nervous system development; regulation of transcription, DNA-dependent; visual perception; ganglion mother cell fate determination. Disease: Wilms Tumor 5
size1 :
0.1 mL
price1 :
255 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
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