GNAT3 Antibody | MyBioSource MBS9402604 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GNAT3 Antibody

catalog :

MBS9402604

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/15.

image 2 :

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/15.

product information

catalog number :

MBS9402604

products type :

Antibody

products full name :

GNAT3 Antibody

products short name :

[GNAT3]

products name syn :

[GDCA]

other names :

[guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein G(t) subunit alpha-3; guanine nucleotide-binding protein G(t) subunit alpha-3; guanine nucleotide binding protein, alpha transducing 3; Gustducin alpha-3 chain]

products gene name :

[GNAT3]

other gene names :

[GNAT3; GNAT3; GDCA]

uniprot entry name :

GNAT3_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

354

specificity :

The antibody detects endogenous levels of total GNAT3 protein.

purity :

Antigen affinity purification.

form :

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

concentration :

1.4 mg/ml

storage stability :

Store at -20°C

tested application :

Immunohistochemistry (IHC)

app notes :

Immunohistochemistry: 1:25-1:100

image1 heading :

Immunohistochemistry (IHC)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to residues near the N terminal of human guanine nucleotide binding protein, alpha transducing 3

other info2 :

Target Name: GNAT3

products categories :

Total protein Ab

products description :

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known as gustducin alpha-3 chain, is a protein that in humans is encoded by the GNAT3 gene. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors.

ncbi gi num :

156139155

ncbi acc num :

NP_001095856.1

ncbi gb acc num :

NM_001102386.1

uniprot acc num :

A8MTJ3

ncbi mol weight :

40,357 Da

ncbi pathways :

ADP Signalling Through P2Y Purinoceptor 12 Pathway (1269353); Activation Of GABAB Receptors Pathway (1268816); Adenylate Cyclase Inhibitory Pathway (1268818); Carbohydrate Digestion And Absorption Pathway (170720); Carbohydrate Digestion And Absorption Pathway (170654); G Alpha (i) Signalling Events Pathway (1269576); G Alpha (s) Signalling Events Pathway (1269575); G Alpha (z) Signalling Events Pathway (1269577); G-protein Activation Pathway (1269585); G-protein Mediated Events Pathway (1269586)

uniprot summary :

G-alpha t3: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide- 1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. Belongs to the G-alpha family. G(i/o/t/z) subfamily. Protein type: G protein; G protein, heterotrimeric alpha G((i/o/t/z)); G protein, heterotrimeric. Chromosomal Location of Human Ortholog: 7q21.11. Cellular Component: photoreceptor outer segment; photoreceptor inner segment; protein complex; apical plasma membrane; plasma membrane; acrosome; heterotrimeric G-protein complex; axoneme. Molecular Function: GTPase activity; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; G-protein coupled photoreceptor activity. Biological Process: response to nicotine; G-protein signaling, coupled to cAMP nucleotide second messenger; synaptic transmission; platelet activation; sensory perception of umami taste; sensory perception of sweet taste; metabolic process; G-protein signaling, adenylate cyclase inhibiting pathway; detection of chemical stimulus involved in sensory perception of bitter taste; blood coagulation; detection of visible light

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage