KLK2 Antibody | MyBioSource MBS9402254 product information

product summary

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company name :

MyBioSource

product type :

antibody

product name :

KLK2 Antibody

catalog :

MBS9402254

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Gel: 10%SDS-PAGE Lysate: 40ug Hela cell Primary antibody: 1/1650 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes

image 2 :

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/80.

product information

catalog number :

MBS9402254

products type :

Antibody

products full name :

KLK2 Antibody

products short name :

[KLK2]

products name syn :

[hK2; hGK-1; KLK2A2]

other names :

[kallikrein-2 isoform 2 preproprotein; Kallikrein-2; kallikrein-2; kallikrein-related peptidase 2; Glandular kallikrein-1; hGK-1; Tissue kallikrein-2]

products gene name :

[KLK2]

other gene names :

[KLK2; KLK2; hK2; hGK-1; KLK2A2; hGK-1]

uniprot entry name :

KLK2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

223

specificity :

The antibody detects endogenous levels of total KLK2 protein.

purity :

Antigen affinity purification.

form :

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

concentration :

3.3 mg/ml

storage stability :

Store at -20°C

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Western blotting: 1:500-1:2000. Immunohistochemistry: 1:100-1:300

image1 heading :

Testing Data

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Peptide. Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human kallikrein-related peptidase 2. SDS-PAGE MW: 29kD

other info2 :

Target Name: KLK2

products categories :

Total protein Ab

products description :

This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants.

ncbi gi num :

50363237

ncbi acc num :

NP_001002231.1

ncbi gb acc num :

NM_001002231.2

uniprot acc num :

P20151

ncbi pathways :

Activated PKN1 Stimulates Transcription Of AR (androgen Receptor) Regulated Genes KLK2 And KLK3 Pathway (1269513); Activation Of Matrix Metalloproteinases Pathway (1270258); Coregulation Of Androgen Receptor Activity Pathway (138085); Degradation Of The Extracellular Matrix Pathway (1270257); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); Extracellular Matrix Organization Pathway (1270244); Metabolism Of Proteins Pathway (1268677); Prostate Cancer Pathway (755440); RHO GTPase Effectors Pathway (1269509)

ncbi summary :

This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]

uniprot summary :

KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; EC 3.4.21.35. Chromosomal Location of Human Ortholog: 19q13.41. Cellular Component: extracellular region. Molecular Function: serine-type endopeptidase activity. Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage