catalog number :
MBS9401982
products full name :
WDR36 Antibody
products short name :
[WDR36]
products name syn :
[GLC1G; UTP21; TAWDRP; TA-WDRP]
other names :
[WD repeat-containing protein 36; WD repeat-containing protein 36; WD repeat-containing protein 36; WD repeat domain 36; T-cell activation WD repeat-containing protein; TA-WDRP]
products gene name :
[WDR36]
other gene names :
[WDR36; WDR36; GLC1G; UTP21; TAWDRP; TA-WDRP; TA-WDRP]
uniprot entry name :
WDR36_HUMAN
specificity :
The antibody detects endogenous levels of total WDR36 protein.
purity :
Antigen affinity purification.
form :
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
concentration :
2.2 mg/ml
storage stability :
Store at -20 degree C
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Western blotting: 1:200-1:1000. Immunohistochemistry: 1:25-1:100
image1 heading :
Testing Data
image2 heading :
Immunohistochemistry (IHC)
image3 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen Type: Peptide. Immunogen Description: Synthetic peptide of human WD repeat domain 36
other info2 :
Target Name: WDR36
products categories :
Total protein Ab
products description :
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG).
ncbi acc num :
NP_644810.1
ncbi gb acc num :
NM_139281.2
ncbi pathways :
Ribosome Biogenesis In Eukaryotes Pathway (199378); Ribosome Biogenesis In Eukaryotes Pathway (199266)
ncbi summary :
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008]
uniprot summary :
WDR36: Involved in T-cell activation and highly co-regulated with IL2. Defects in WDR36 are the cause of primary open angle glaucoma type 1G (GLC1G). Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Protein type: Nucleolus. Chromosomal Location of Human Ortholog: 5q22.1. Cellular Component: small subunit processome; nucleolus. Biological Process: retinal homeostasis; visual perception; response to stimulus; regulation of axon extension; rRNA processing. Disease: Glaucoma 1, Open Angle, G