COL18A1 antibody | MyBioSource MBS9401734 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

COL18A1 antibody

catalog :

MBS9401734

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts of A431 cell lines, using COL18A1 antibody.

product information

catalog number :

MBS9401734

products type :

Antibody

products full name :

COL18A1 antibody

products short name :

[COL18A1]

products name syn :

[FLJ27325; FLJ34914; KNO; KNO1; KS; MGC74745]

other names :

[collagen alpha-1(XVIII) chain isoform 1 preproprotein; Collagen alpha-1(XVIII) chain; collagen alpha-1(XVIII) chain; collagen, type XVIII, alpha 1]

products gene name :

[COL18A1]

other gene names :

[COL18A1; COL18A1; KS; KNO; KNO1]

uniprot entry name :

COIA1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1516

specificity :

The antibody detects endogenous level of total COL18A1 antibody.

purity :

Antibodies were purified by affinity purification using immunogen.

form :

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1.0 mg/ml

storage stability :

Store at -20°C

tested application :

Western Blot (WB)

app notes :

Western blotting: 1:500 - 1:2000

image1 heading :

Western Blot (WB)

other info1 :

Immunogen Type: Peptide. Immunogen Description: A synthetic peptide of human COL18A1.

other info2 :

Target Name: COL18A1. SDS-PAGE MW: 178 kD

products categories :

Total protein Ab

products description :

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

ncbi gi num :

110611235

ncbi acc num :

NP_085059.2

ncbi gb acc num :

NM_030582.3

uniprot acc num :

P39060

ncbi pathways :

Activation Of Matrix Metalloproteinases Pathway (1270258); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (1270247); Collagen Biosynthesis And Modifying Enzymes Pathway (1270246); Collagen Degradation Pathway (1270259); Collagen Formation Pathway (1270245); Degradation Of The Extracellular Matrix Pathway (1270257); Direct P53 Effectors Pathway (137939); Extracellular Matrix Organization Pathway (1270244); FOXA1 Transcription Factor Network Pathway (137979); Integrin Cell Surface Interactions Pathway (1270260)

ncbi summary :

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

uniprot summary :

COL18A1: COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1). An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele. Belongs to the multiplexin collagen family. 3 isoforms of the human protein are produced by alternative promoter. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: extracellular matrix; extracellular space; collagen; endoplasmic reticulum lumen; extracellular region; basement membrane. Molecular Function: identical protein binding; protein binding; metal ion binding; structural molecule activity. Biological Process: response to drug; extracellular matrix disassembly; collagen catabolic process; negative regulation of cell proliferation; organ morphogenesis; extracellular matrix organization and biogenesis; visual perception; positive regulation of cell proliferation; endothelial cell morphogenesis; angiogenesis; cell adhesion; response to hydrostatic pressure; positive regulation of cell migration. Disease: Knobloch Syndrome 1

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage