MCTS1 Antibody | MyBioSource MBS9401306 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

MCTS1 Antibody

catalog :

MBS9401306

quantity :

0.1 mL

price :

255 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Gel: 10%SDS-PAGE Lysates (from left to right): Jurkat and K562 cell, PC3 and A549 cell Amount of lysate: 40ug per lane Primary antibody: 1/200 dilution Secondary antibody dilution: 1/8000 Exposure time: 3 minutes

image 2 :

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/30.

product information

catalog number :

MBS9401306

products type :

Antibody

products full name :

MCTS1 Antibody

products short name :

[MCTS1]

products name syn :

[MCT1; MCT-1]

other names :

[malignant T-cell-amplified sequence 1 isoform 2; Malignant T-cell-amplified sequence 1; malignant T-cell-amplified sequence 1; malignant T cell amplified sequence 1; Multiple copies T-cell malignancies]

products gene name :

[MCTS1]

other gene names :

[MCTS1; MCTS1; MCT1; MCT-1; MCT1; MCT-1]

uniprot entry name :

MCTS1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

182

specificity :

The antibody detects endogenous levels of total MCTS1 protein.

purity :

Antigen affinity purification.

form :

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

concentration :

1.3 mg/ml

storage stability :

Store at -20°C

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Western blotting: 1:200-1:1000. Immunohistochemistry: 1:50-1:200

image1 heading :

Testing Data

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen Type: Recombinant Protein. Immunogen Description: Full length fusion protein. SDS-PAGE MW: 21 kDa

other info2 :

Target Name: MCTS1

products categories :

Total protein Ab

products description :

MCTS1 (malignant T cell amplified sequence 1), also known as MCT1, is a 181 amino acid protein that is ubiquitously expressed and localizes to the cytoplasm of cells. MCTS1 may play a role in cell cycle regulation by decreasing cell doubling time and by shortening the duration of G1 transit time and G1/S transition. The protein level of Cdk4 and Cdk6 kinases activity and cyclin D1 is enhanced by expression of MCTS1. As a translation enhancer, MCTS1 recruits DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile. MCTS1 promotes lymphoid tumor development and contributes to the pathogenesis and progression of breast cancer. MCTS1 positively regulates phosphorylation of ERK1 and ERK2.

ncbi gi num :

212276121

ncbi acc num :

NP_001131026.1

ncbi gb acc num :

NM_001137554.1

uniprot acc num :

Q9ULC4

uniprot summary :

MCTS1: Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density-regulated protein/DENR and binds to the cap complex of the 5 -terminus of mRNAs, subsequently altering the mRNA translation profile; Up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma- irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Belongs to the MCTS1 family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Tumor suppressor. Chromosomal Location of Human Ortholog: Xq24. Cellular Component: cytoplasm; plasma membrane. Molecular Function: translation initiation factor activity. Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of growth; positive regulation of cell proliferation; ribosome disassembly; cell cycle; response to DNA damage stimulus; formation of translation preinitiation complex

size1 :

0.1 mL

price1 :

255 USD

more info or order :

MyBioSource product webpage