antibody

ASH1 Antibody

MBS9401209

0.1 mL

320 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

ASH1 Antibody

[ASH1]

[ASH1; Histone-lysine N-methyltransferase ASH1L; histone-lysine N-methyltransferase ASH1L; ash1 (absent, small, or homeotic)-like (Drosophila); ASH1-like protein; huASH1; Absent small and homeotic disks protein 1 homolog; Lysine N-methyltransferase 2H]

[ASH1]

[ASH1L; ASH1L; ASH1; KMT2H; ASH1L1; KIAA1420; KMT2H; huASH1]

ASH1L_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

2969

Not yet tested in other species

Affinity purified

PBS, pH 7.4 with 0.02% Sodium Azide

1.0 mg/ml

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

ELISA (EIA), Western Blot (WB)

Testing Data

Immunogen Type: Peptide-KLH. Immunogen Description: Synthetic peptide conjugated to KLH

Target Name: ASH1

Total protein Ab

7739725

AAF68983.1

Lysine Degradation Pathway (82956); Lysine Degradation Pathway (320); Tight Junction Pathway (83071); Tight Junction Pathway (482)

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]

ASH1L: a protein methyltransferase that specifically methylates K36 of histone H3 (H3K36me). A member of the trithorax group (trxG) of transcriptional activators that is required for proper expression of Hox genes and is preferentially expressed in haematopoietic stem cells. Widely expressed, with high levels in brain, heart and kidney. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. Protein type: Cell adhesion; EC 2.1.1.43; Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine; Methyltransferase. Chromosomal Location of Human Ortholog: 1q22. Cellular Component: nucleoplasm; Golgi apparatus; tight junction; cytoplasm; chromosome; nucleus. Molecular Function: DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); chromatin binding. Biological Process: transcription from RNA polymerase II promoter; cell-cell signaling; negative regulation of MAPKKK cascade; interleukin-6 production; histone H3-K4 methylation; negative regulation of acute inflammatory response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of I-kappaB kinase/NF-kappaB cascade; DNA packaging

0.1 mL

320 USD