CD155 Polyclonal Antibody | MyBioSource MBS9401179 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD155 Polyclonal Antibody

catalog :

MBS9401179

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Western Blot analysis of KB cells using CD155 Polyclonal Antibody

image 2 :

Western Blot analysis of KB cells using CD155 Polyclonal Antibody

product information

catalog number :

MBS9401179

products type :

Antibody

products full name :

CD155 Polyclonal Antibody

products short name :

[CD155]

products name syn :

[PVR; PVS; Poliovirus receptor; Nectin-like protein 5; NECL-5; CD155]

other names :

[poliovirus receptor isoform beta; Poliovirus receptor; poliovirus receptor; poliovirus receptor; Nectin-like protein 5; NECL-5; CD_antigen: CD155]

products gene name :

[CD155]

other gene names :

[PVR; PVR; PVS; HVED; CD155; NECL5; TAGE4; Necl-5; PVS; NECL-5]

uniprot entry name :

PVR_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

372

specificity :

CD155 Polyclonal Antibody detects endogenous levels of CD155 protein.

purity :

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

form :

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Store at -20°C/1 year

tested application :

Western Blot (WB), ELISA (EIA)

app notes :

Western Blot: 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot(WB)

other info1 :

Immunogen Type: peptide. Immunogen Description: Synthesized peptide derived from the Internal region of human CD155. SDS-PAGE MW: 45kd

other info2 :

Target Name: CD155

products categories :

Total protein Ab

ncbi gi num :

209413728

ncbi acc num :

NP_001129240.1

ncbi gb acc num :

NM_001135768.2

uniprot acc num :

P15151

ncbi pathways :

Adaptive Immune System Pathway (1269171); Adherens Junctions Interactions Pathway (1270234); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (1270232); Cell-Cell Communication Pathway (1270231); Cell-cell Junction Organization Pathway (1270233); Immune System Pathway (1269170); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1269201); Nectin Adhesion Pathway (138054)

ncbi summary :

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

uniprot summary :

PVR: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. Belongs to the nectin family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Immunoglobulin superfamily; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: extracellular space; cell surface; focal adhesion; cytoplasm; plasma membrane; integral to membrane. Molecular Function: viral receptor activity; protein binding; receptor activity; cell adhesion molecule binding. Biological Process: intercellular junction assembly and maintenance; entry of virus into host cell; cell-cell adhesion; regulation of immune response; cell migration; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; response to virus; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

255

more info or order :

MyBioSource product webpage