product summary
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company name :
MyBioSource
product type :
antibody
product name :
MRCKB Antibody
catalog :
MBS9401076
quantity :
0.05 mL
price :
200 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry
more info or order :
image
image 1 :
Western blot analysis of extracts from COLO cells, using MRCKB antibody.
image 2 :
Immunohistochemistry analysis of paraffin-embedded human brain tissue using MRCKB antibody.
product information
catalog number :
MBS9401076
products type :
Antibody
products full name :
MRCKB Antibody
products short name :
[MRCKB]
products name syn :
[CDC42-binding protein kinase beta; CDC42BPB; EC 2.7.11.1; MRCK-beta]
other names :
[serine/threonine-protein kinase MRCK beta; Serine/threonine-protein kinase MRCK beta; serine/threonine-protein kinase MRCK beta; CDC42 binding protein kinase beta (DMPK-like); CDC42-binding protein kinase beta; CDC42BP-beta; DMPK-like beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; MRCK beta; Myotonic dystrophy protein kinase-like beta]
products gene name :
[MRCKB]
other gene names :
[CDC42BPB; CDC42BPB; MRCKB; CDC42BP-beta; MRCK beta; Myotonic dystrophy protein kinase-like beta]
uniprot entry name :
MRCKB_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
1711
specificity :
The antibody detects endogenous levels of total MRCKB protein.
purity :
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
form :
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
concentration :
1.0 mg/ml
storage stability :
Store at -20 degree C
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Western blotting: 1:500~1:3000. Immunohistochemistry: 1:50~1:100
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen Type: Peptide. Immunogen Description: Synthesized peptide derived from internal of human MRCKB.
other info2 :
Target Name: MRCKB
products categories :
Total protein Ab
products description :
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.Nakajima D., DNA Res. 9:99-106(2002).Olsen J.V., Cell 127:635-648(2006).Hirosawa M., DNA Res. 6:329-336(1999).
ncbi gi num :
115527097
ncbi acc num :
NP_006026.3
ncbi gb acc num :
NM_006035.3
uniprot acc num :
Q9Y5S2
ncbi mol weight :
194kd
ncbi summary :
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]
uniprot summary :
MRCKB: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. Protein type: Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; AGC group; DMPK family; GEK subfamily. Chromosomal Location of Human Ortholog: 14q32.3. Cellular Component: cytoskeleton; leading edge; cytoplasm; plasma membrane; actomyosin; intercellular junction. Molecular Function: protein serine/threonine kinase activity; Rho GTPase binding; magnesium ion binding; ATP binding; protein kinase activity. Biological Process: cell migration; regulation of catalytic activity; actomyosin structure organization and biogenesis; actin cytoskeleton reorganization; establishment and/or maintenance of cell polarity; cytoskeleton organization and biogenesis; signal transduction; protein amino acid phosphorylation
size1 :
0.05 mL
price1 :
200 USD
size2 :
0.1 mL
price2 :
255
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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