PSMA Antibody | MyBioSource MBS9400539 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PSMA Antibody

catalog :

MBS9400539

quantity :

0.05 mL

price :

200 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis of extracts from MCF and PC3 cells using PSMA Antibody .

product information

catalog number :

MBS9400539

products type :

Antibody

products full name :

PSMA Antibody

products short name :

[PSMA]

products name syn :

[FGCP; Folate hydrolase 1; FOLH; FOLH1; GCP2]

other names :

[glutamate carboxypeptidase 2 isoform 2; Glutamate carboxypeptidase 2; glutamate carboxypeptidase 2; folate hydrolase (prostate-specific membrane antigen) 1; Cell growth-inhibiting gene 27 protein; Folate hydrolase 1; Folylpoly-gamma-glutamate carboxypeptidase; FGCP; Glutamate carboxypeptidase II; GCPII; Membrane glutamate carboxypeptidase; mGCP; N-acetylated-alpha-linked acidic dipeptidase I; NAALADase I; Prostate-specific membrane antigen; PSM; PSMA; Pteroylpoly-gamma-glutamate carboxypeptidase]

products gene name :

[PSMA]

other gene names :

[FOLH1; FOLH1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; FOLH; NAALAD1; PSM; PSMA; FGCP; GCPII; mGCP; NAALADase I; PSM; PSMA]

uniprot entry name :

FOLH1_HUMAN

clonality :

polyclonal

host :

rabbit

reactivity :

Human

sequence length :

719

specificity :

The antibody detects endogenous level of total PSMA protein.

purity :

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

form :

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

concentration :

1.0 mg/ml

storage stability :

Store at -20°C

tested application :

Western Blot (WB)

app notes :

Western blotting: 1:500~1:1000

image1 heading :

Western Blot (WB)

other info1 :

Immunogen Type: Peptide-KLH. Immunogen Description: Peptide sequence around aa.738~750 (A-A-E-T-L) derived Human from PSMA. SDS-PAGE MW: 84 kD

other info2 :

Target Name: PSMA

products categories :

Total protein Ab

products description :

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4and isoform PSM-5would appear to be physiologically irrelevant. Involved in prostate tumor progression.

ncbi gi num :

62548858

ncbi acc num :

NP_001014986.1

ncbi gb acc num :

NM_001014986.1

uniprot acc num :

Q04609

ncbi mol weight :

50,090 Da

ncbi pathways :

Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Metabolic Pathways (132956); One Carbon Metabolism Pathway (198756); Vitamin Digestion And Absorption Pathway (199556); Vitamin Digestion And Absorption Pathway (199538)

ncbi summary :

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

uniprot summary :

FOLH1: Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Belongs to the peptidase M28 family. M28B subfamily. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; EC 3.4.17.21; Protease. Chromosomal Location of Human Ortholog: 11p11.2. Cellular Component: membrane; integral to plasma membrane; cytoplasm. Molecular Function: dipeptidase activity; peptidase activity; metallopeptidase activity; carboxypeptidase activity; metal ion binding. Biological Process: folic acid and derivative metabolic process; proteolysis

size1 :

0.05 mL

price1 :

200 USD

size2 :

0.1 mL

price2 :

255

more info or order :

MyBioSource product webpage